ArticleNano letters2018
Active Delivery of Single DNA Molecules into a Plasmonic Nanopore for Label-Free Optical Sensing.
Article in Nano letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Light-Driven, Phase-Locked Protein Pumping Through a Single Plasmonic Optofluidic Nanopore.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Interrogating nanopores with light: optipore sensing for single molecule analyses.Journal of nanobiotechnology · 2026Review
- Spatiotemporal Raman probing of molecular transport in sub-2-nm plasmonic quasi-2D nanochannels.Science advances · 2026Article
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- Plasmonic Nanostructure Biosensors: A Review.Sensors (Basel, Switzerland) · 2023Review
- Plasmonic Bowl-Shaped Nanopore for Raman Detection of Single DNA Molecules in Flow-Through.Nano letters · 2023Article
- Review
- Localized Nanopore Fabrication via Controlled Breakdown.Nanomaterials (Basel, Switzerland) · 2022Review
- The perspectives of broadband metasurfaces and photo-electric tweezer applications.Nanophotonics (Berlin, Germany) · 2022Review
- Label-Free Optical Analysis of Biomolecules in Solid-State Nanopores: Toward Single-Molecule Protein Sequencing.ACS photonics · 2022Review
- Enhanced Optical Spectroscopy for Multiplexed DNA and Protein-Sequencing with Plasmonic Nanopores: Challenges and Prospects.Analytical chemistry · 2022Article
- FIB-milled plasmonic nanoapertures allow for long trapping times of individual proteins.iScience · 2021Article
- Recent advances in integrated solid-state nanopore sensors.Lab on a chip · 2021Review
- Single-Entity Electrochemistry for Digital Biosensing at Ultralow Concentrations.Analytical chemistry · 2021Article
- Plasmonic Biosensors for Single-Molecule Biomedical Analysis.Biosensors · 2021Review
- Plasmonic tweezers: for nanoscale optical trapping and beyond.Light, science & applications · 2021Review
- Article
- Sensitivity-Enhancing Strategies in Optical Biosensing.Small (Weinheim an der Bergstrasse, Germany) · 2021Review
- Enhancing Surface Capture and Sensing of Proteins with Low-Power Optothermal Bubbles in a Biphasic Liquid.Nano letters · 2020Article
- Overcoming Diffusion-Limited Trapping in Nanoaperture Tweezers Using Opto-Thermal-Induced Flow.Nano letters · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Plasmon resonance biosensors provide ultimate sensitivity at the single-molecule level. This sensitivity is, however, associated with a nanometer-sized confined hotspot, and molecular transport toward the sensor relies on inefficient diffusion. Here, we combine a plasmonic nanoantenna with a solid-state nanopore and demonstrate that single DNA molecules can be efficiently delivered to the plasmonic hotspots and detected in a label-free manner at submillisecond acquisition rates by monitoring the backscattered light intensity from the plasmonic nanoantennas. Our method realizes a better than 200 μs temporal resolution together with a down to subsecond waiting time, which is orders of magnitude better than traditional single-molecule plasmonic resonance sensing methods. Furthermore, the electric field applied to the nanopore can actively drive biomolecules away from the hotspot, preventing molecules to permanently bind to the gold sensor surface and allowing efficient reuse of the sensor. Our plasmonic nanopore sensor thus significantly outperforms conventional plasmon resonance sensors and provides great opportunities for high-throughput optical single-molecule-sensing assays.
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Registered trials
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