SynthesisEnvironmental science and pollution research international2019
Relationship between cadmium content in semen and male infertility: a meta-analysis.
Synthesis in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Current risk factors for male infertility and semen parameters: an umbrella review of systematic reviews and meta-analyses.Asian journal of andrology · 2026Pooled it
- Combined Effects of 7,12-dimethylbenz[a]anthracene (DMBA) with Cobalt, Cadmium, or Zinc on Fertility in Rats.International journal of fertility & sterility · 2026Article
- Impact of Cadmium Toxicity on Testicular Function: Risk of Male Infertility.Life (Basel, Switzerland) · 2026Review
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Evaluation of the Reversibility of Cadmium-Induced Testicular Toxicity Following Recovery Alone or with Zinc Supplementation.International journal of environmental research and public health · 2025Article
- Using Life's Essential 8 and heavy metal exposure to determine infertility risk in American women: a machine learning prediction model based on the SHAP method.Frontiers in endocrinology · 2025Article
- The Smoky Impact of Nicotinic Acetylcholine Receptors on Testicular Function.Journal of clinical medicine · 2024Review
- Effect ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Dietary trends and the decline in male reproductive health.Hormones (Athens, Greece) · 2023Review
- Evolutionary Implications of Environmental Toxicant Exposure.Biomedicines · 2022Review
- Review
- Exposure to low-dose cadmium induces testicular ferroptosis.Ecotoxicology and environmental safety · 2022Article
- Impact of Heavy Metals on Human Male Fertility-An Overview.Antioxidants (Basel, Switzerland) · 2021Review
- Interaction effect of polycyclic aromatic hydrocarbon metabolites and cadmium on semen quality in nonsmokers.Environmental science and pollution research international · 2020Article
- Toxicological Effects of Cadmium on Mammalian Testis.Frontiers in genetics · 2020Review
- AnJournal of human reproductive sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Meta-analysis with high-quality studies can provide superior evidence. In this paper, we use meta-analysis to analyze the relationship between cadmium (Cd) content in semen and male infertility, and then objectively evaluate the effect of Cd on sperm quality. The objectives of this study were to update our understanding of infertility and to provide evidence to treat and prevent the infertility. We searched potentially relevant studies that were published from establishing database data to April 2018. Articles came from the databases of CNKI, Wanfang, VIP, PubMed, CMCI, and EMBASE. A total of 11 articles were included. We gathered the mean and variance of the infertility group and the control group to compare the Cd content in two groups. In total, the 11 studies include 1707 subjects, 1093 of which were in the infertility group and 614 of which were in the control group. We can get some information from this meta-analysis: SMD = 0.50 (95% Cl 0.39-0.61), Z = 8.92, P < 0.05; the funnel plot of the meta-analysis shows incomplete symmetry, which may have the publication bias. Therefore, the high content of Cd in semen is a causative factor of infertility. The Cd content in semen can be used as an indicator of sperm quality.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.