Evidence map›Paper›PMID 30460625›Full record

ArticleMolecular imaging and biology2019

Preclinical SPECT Imaging of Choroidal Neovascularization in Mice Using Integrin-Binding [

Seong Joon Ahn, Ho-Young Lee, Hye Kyoung Hong, Jae Ho Jung, Ji Hyun Park, Kyu Hyung Park, Sang Eun Kim, Se Joon Woo, Byung Chul Lee

Abstract read
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In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Seong Joon AhnDepartment of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumidong, Bundanggu, Seongnam, 13620, Republic of Korea.
Ho-Young LeeDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumidong, Bundanggu, Seongnam, 13620, Republic of Korea.
Hye Kyoung HongDepartment of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumidong, Bundanggu, Seongnam, 13620, Republic of Korea.
Jae Ho JungDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumidong, Bundanggu, Seongnam, 13620, Republic of Korea.
Ji Hyun ParkDepartment of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumidong, Bundanggu, Seongnam, 13620, Republic of Korea.
Kyu Hyung ParkDepartment of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumidong, Bundanggu, Seongnam, 13620, Republic of Korea.
Sang Eun KimDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumidong, Bundanggu, Seongnam, 13620, Republic of Korea.
Se Joon WooDepartment of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumidong, Bundanggu, Seongnam, 13620, Republic of Korea. sejoon1@snu.ac.kr.ORCID 0000-0003-3692-7169
Byung Chul LeeDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumidong, Bundanggu, Seongnam, 13620, Republic of Korea. leebc@snu.ac.kr.
Seoul National University Bundang Hospital · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntegrin ɑ PROCEDURES: To induce CNV in animals, the right eyes of C57BL/6 mice were treated with retinal argon laser photocoagulation. CNV formation was confirmed on immunohistopathological examination of retinal and choroidal tissues. To explore the association of integrin with angiogenesis, integrin mRNA expression in the retinal and choroidal tissues was measured using real-time reverse transcriptase-polymerase chain reaction. For in vivo imaging, mice were intravenously injected with [

resultsImmunohistopathological examination revealed that CNV lesions showed intense fluorescein isothiocyanate (FITC)-D-[c(RGDfK)]

conclusionsSPECT imaging using an integrin ɑ

Indexed as

Tomography, Emission-Computed, Single-PhotonAnimalsChoroidal NeovascularizationIntegrin alphaVbeta3Mice, Inbred C57BLOrganotechnetium CompoundsPeptides, CyclicProtein BindingReproducibility of ResultsRNA, MessengerTomography, X-Ray Computed99mTc-IDA-D-(c(RGDfK))2Integrin alphaVbeta3Organotechnetium CompoundsPeptides, CyclicRNA, MessengerAge-related macular degenerationChoroidal neovascularizationFunctional imagingIntegrinMolecular imagingRGD peptide

Identifiers

PMID30460625
OpenAlexW2901738539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.