Evidence map›Paper›PMID 30460578›Full record

ArticleDiabetologia2019

Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease and mortality in the general population.

Robert P van Waateringe, Bernardina T Fokkens, Sandra N Slagter, Melanie M van der Klauw, Jana V van Vliet-Ostaptchouk, Reindert Graaff, Andrew D Paterson, Andries J Smit, Helen L Lutgers, Bruce H R Wolffenbuttel

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07314957 (The Role of Lifestyle in Maintaining Health), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07314957 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Role of Lifestyle in Maintaining Health: Biological, Psychological and Social Responses of the Organism to Lifestyle

TypeinterventionalSponsorUniversity of ZadarRan2026 to 2027Enrolled120ConditionsMetabolic Syndrome, Inactivity/Low Levels of Exercise, Unhealthy Diet, Unhealthy Alcohol UseArmsIntervention of physical activity, Mediterranean Diet Education, Behavioral: Stress-Resilience Training
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Pentosidine Is Associated With Cortical Bone Geometry and Insulin Resistance in Otherwise Healthy Children.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Robert P van WaateringeDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, HPC AA31 9700 RB, Groningen, the Netherlands.
Bernardina T FokkensDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Sandra N SlagterDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, HPC AA31 9700 RB, Groningen, the Netherlands.
Melanie M van der KlauwDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, HPC AA31 9700 RB, Groningen, the Netherlands.
Jana V van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, HPC AA31 9700 RB, Groningen, the Netherlands.
Reindert GraaffDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, HPC AA31 9700 RB, Groningen, the Netherlands.
Andrew D PatersonProgram in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada.
Andries J SmitDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Helen L LutgersDepartment of Internal Medicine, Medical Center Leeuwarden, Leeuwarden, the Netherlands.
Bruce H R WolffenbuttelDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, HPC AA31 9700 RB, Groningen, the Netherlands. bwo@umcg.nl.ORCID 0000-0001-9262-6921
University Medical Center Groningen · NLHospital for Sick Children · CAMedisch Centrum Leeuwarden · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisEarlier studies have shown that skin autofluorescence measured with an AGE reader estimates the accumulation of AGEs in the skin, which increases with ageing and is associated with the metabolic syndrome and type 2 diabetes. In the present study, we examined whether the measurement of skin autofluorescence can predict 4 year risk of incident type 2 diabetes, cardiovascular disease (CVD) and mortality in the general population.

methodsFor this prospective analysis, we included 72,880 participants of the Dutch Lifelines Cohort Study, who underwent baseline investigations between 2007 and 2013, had validated baseline skin autofluorescence values available and were not known to have diabetes or CVD. Individuals were diagnosed with incident type 2 diabetes by self-report or by a fasting blood glucose ≥7.0 mmol/l or HbA

resultsAfter a median follow-up of 4 years (range 0.5-10 years), 1056 participants (1.4%) had developed type 2 diabetes, 1258 individuals (1.7%) were diagnosed with CVD, while 928 (1.3%) had died. Baseline skin autofluorescence was elevated in participants with incident type 2 diabetes and/or CVD and in those who had died (all p < 0.001), compared with individuals who survived and remained free of the two diseases. Skin autofluorescence predicted the development of type 2 diabetes, CVD and mortality, independent of several traditional risk factors, such as the metabolic syndrome, glucose and HbA CONCLUSIONS/

interpretationThe non-invasive skin autofluorescence measurement is of clinical value for screening for future risk of type 2 diabetes, CVD and mortality, independent of glycaemic measures and the metabolic syndrome.

Indexed as

AdultAgedBlood GlucoseCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleHumansIncidenceMaleMiddle AgedOptical ImagingProspective StudiesRisk FactorsSkinBlood GlucoseAgeingCardiovascularDiabetesMortalityPredictionSkin autofluorescence

Identifiers

PMID30460578
PMCPMC6323092
OpenAlexW2901028800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.