Evidence map›Paper›PMID 30460515›Full record

ArticlePsychopharmacology2019

Cannabinoid-induced lower lip retraction in rats.

Girish R Chopda, Spyros P Nikas, Rishi Sharma, Shashank Kulkarni, Alexandros Makriyannis, Carol A Paronis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Girish R ChopdaCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Spyros P NikasCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Rishi SharmaCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Shashank KulkarniCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Alexandros MakriyannisCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Carol A ParonisCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA. cparonis@mclean.harvard.edu.
Northeastern University · US

Funding

Cannabinergic Medications for Methamphetamine AddictionR37DA023142 · NIDA · NORTHEASTERN UNIVERSITY · PI MAKRIYANNIS, ALEXANDROS · 2007 to 2016
$7.1M
Behavioral Pharmacology of Synthetic CannabinoidsR01DA043700 · NIDA · MCLEAN HOSPITAL · PI PARONIS, CAROL A · 2018 to 2022
$2.7M
National Institute on Drug Abuse DA023142National Institute on Drug Abuse DA043700NIDA NIH HHS R01 DA043700NIDA NIH HHS R37 DA023142
6 · The paper itself

Abstract

rationaleLower lip retraction (LLR) in rats has been described as a distinctive effect of 5-HT

objectivesTo pharmacologically characterize cannabinoid-induced LLR in rats.

methodsLower lip retraction was scored using a 3-point scale for up to 6 h after injection of the cannabinoid agonists Δ

resultsAll three cannabinoid agonists produced LLR. Effects of AM2389 were attenuated by both rimonabant and WAY100635 whereas effects of 8-OH-DPAT were antagonized by WAY 100635 but not by rimonabant. Pretreatment with 1 mg/kg Δ

conclusionsCannabinoid agonists produce LLR in rats, an effect heretofore ascribed only to activity at 5-HT

Indexed as

8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsBenzopyransCannabinoid Receptor AgonistsCannabinoidsDose-Response Relationship, DrugDronabinolFemaleLipRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Receptor, Serotonin, 5-HT1ASerotonin Receptor Agonists3-(1-hexylcyclobut-1-yl)-6a,7,8,9,10,10a-hexahydro-6,6-dimethyl-6H-dibenzo(b,d)pyran-1,9 diol8-Hydroxy-2-(di-n-propylamino)tetralinBenzopyransCannabinoid Receptor AgonistsCannabinoidsDronabinolReceptor, Cannabinoid, CB1Receptor, Serotonin, 5-HT1ASerotonin Receptor Agonists8-OH-DPATAM2389AM7499CannabinoidLower lip retractionΔ9-THC

Identifiers

PMID30460515
PMCPMC6527497
OpenAlexW2901260704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.