ArticlePediatric nephrology (Berlin, Germany)2019
Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage.
Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Prediction of Severe Acute Kidney Injury by Positive Renal Angina Index and Cystatin C in Children with Septic Shock: A Diagnostic Accuracy Study.Indian pediatrics · 2026Article
- Examining commonly used equations for estimating the glomerular filtration rate (GFR) in a healthy cohort of children and adolescents.BMC nephrology · 2026Observational
- Measuring and estimating the GFR in children: state of the art in 2025.Pediatric nephrology (Berlin, Germany) · 2025Review
- Acute kidney injury in paediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2025Review
- Diagnostic Accuracy of Furosemide Stress Test and Cystatin-C for Predicting Acute Kidney Injury Progression in Children: A Prospective Cohort Study.Indian journal of pediatrics · 2025Article
- Novel acute kidney injury biomarkers and their utility in children and adolescents-overview.Italian journal of pediatrics · 2025Review
- Continuous reference intervals for plasma cystatin C and creatinine in Vietnamese children.EJIFCC · 2024Article
- Extending the cystatin C based EKFC-equation to children - validation results from Europe.Pediatric nephrology (Berlin, Germany) · 2024Article
- Exploring Renal Function Assessment: Creatinine, Cystatin C, and Estimated Glomerular Filtration Rate Focused on the European Kidney Function Consortium Equation.Annals of laboratory medicine · 2024Review
- Determination of cystatin C reference interval for children in Croatia.Biochemia medica · 2024Article
- Influence of growth and metabolic markers on hs-troponin T and NT-proBNP levels in healthy children.Endocrine connections · 2023Article
- Low agreement between various eGFR formulae in pediatric and young adult ADPKD patients.Pediatric nephrology (Berlin, Germany) · 2023Article
- Development of a biomarker signature using grating-coupled fluorescence plasmonic microarray for diagnosis of MIS-C.Frontiers in bioengineering and biotechnology · 2023Article
- Elevation of preoperative cystatin C as an early predictor of contrast-induced nephropathy in patients receiving percutaneous coronary intervention.Singapore medical journal · 2022Article
- Current State of Pediatric Reference Intervals and the Importance of Correctly Describing the Biochemistry of Child Development: A Review.JAMA pediatrics · 2022Review
- High serum cystatin C levels in juvenile myelomonocytic leukemia patients without abnormal kidney function.Pediatric nephrology (Berlin, Germany) · 2022Article
- Cystatin C relates to metabolism in healthy, pubertal adolescents.Pediatric nephrology (Berlin, Germany) · 2022Article
- The Use of Renal Biomarkers in Pediatric Cardiac Patients With Acute Kidney Injury.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Cystatin C: best biomarker for acute kidney injury and estimation of glomerular filtration rate in childhood cirrhosis.European journal of pediatrics · 2021Article
- Folate and Cobalamin Serum Levels in Healthy Children and Adolescents and Their Association with Age, Sex, BMI and Socioeconomic Status.Nutrients · 2021Article
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Authors and funding
11 authors.
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Abstract
backgroundThis study aims to establish age- and gender-specific cystatin C (CysC) reference values for healthy infants, children, and adolescents and to relate them to pubertal stage, height, weight, and body mass index (BMI).
methodsSerum CysC and creatinine levels of 6217 fasting, morning venous blood samples from 2803 healthy participants of the LIFE Child study (age 3 months to 18 years) were analyzed by an immunoassay. Recruitment started in 2011; 1636 participants provided at least one follow-up measurement. Percentiles for CysC were calculated. Age- and gender-related effects of height, weight, BMI, and puberty status were assessed through linear regression models.
resultsOver the first 2 years of life, median CysC levels decrease depending on height (ß = - 0.010 mg/l/cm, p < 0.001) and weight (ß = - 0.033 mg/l/kg, p < 0.001) from 1.06 to 0.88 mg/l for males and from 1.04 to 0.87 mg/l for females. Following the second year of age, the levels remain stable for eight years. From 11 to 14 years of age, there is an increase of median CysC levels in males to 0.98 mg/l and a decrease in females to 0.86 mg/l. The change is associated with puberty (ß = 0.105 mg/l/Tanner stage, p < 0.001 in males and ß = - 0.093 mg/l/Tanner stage, p < 0.01 in females) and in males with height (ß = 0.003 mg/l/cm, p < 0.001).
conclusionsCysC levels depend on age, gender, and height, especially during infancy and puberty. We recommend the use of age- and gender-specific reference values for CysC serum levels for estimating kidney function in clinical practice.
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