SynthesisJournal of neurology2019
Quality of life in idiopathic dystonia: a systematic review.
Synthesis in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of Cognition in Cervical Dystonia.Neuropsychology review · 2024Pooled it
- Quality of life outcomes after deep brain stimulation in dystonia: A systematic review.Parkinsonism & related disorders · 2020Pooled it
- Participation restrictions in isolated cervical dystonia: a convergent mixed-methods study.Journal of rehabilitation medicine · 2026Article
- Quality of Life and Related Factors in Children With Dystonia.Brain and behavior · 2026Article
- Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia.Annals of clinical and translational neurology · 2026Article
- More than a Movement Disorder: Non-Motor Features and Future Directions in Dystonia Research.Brain sciences · 2025Review
- Trends, Hotspots, and Future Directions of Research on Pain in Dystonia: A Bibliometric Analysis.Brain and behavior · 2025Article
- Non-Motor Symptoms and Health-Related Quality of Life in Patients with Isolated Dystonia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Patient Burden in Dystonia Diagnosis and Botulinum Toxin Treatment: A Nationwide Survey in Turkey.Brain and behavior · 2025Article
- Social determinants of health and health-related quality of life in individuals with isolated dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Regional abnormalities in the hippocampus and verbal memory impairment in craniofacial dystonia.Frontiers in neuroscience · 2025Article
- EEG-based sensorimotor neurofeedback for motor neurorehabilitation in children and adults: A scoping review.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Health-Related Quality of Life in Romanian Patients with Dystonia: An Exploratory Study.Journal of clinical medicine · 2024Article
- Prevalence and temporal relationship of clinical co-morbidities in idiopathic dystonia: a UK linkage-based study.Journal of neurology · 2024Article
- Longitudinal predictors of health-related quality of life in isolated dystonia.Journal of neurology · 2024Article
- Relations between nonmotor manifestations and motor disorders in patients with benign essential blepharospasm.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Assessing the Severity of Cervical Dystonia: Ask the Doctor or Ask the Patient?Movement disorders clinical practice · 2023Article
- Effects of the periocular botulinum toxin on the ocular surface and anterior chamber: a prospective study in patients with hemifacial spasm and blepharospasm.International ophthalmology · 2023Article
- Pain Reduction in Cervical Dystonia Following Treatment with IncobotulinumtoxinA: A Pooled Analysis.Toxins · 2023Article
- Development of a New Care Pathway for Depression and Anxiety in Adult-Onset Isolated Dystonia.Movement disorders clinical practice · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDystonia is characterised by sustained muscular contractions frequently producing repetitive, twisting and patterned movements. The primary aim of this systematic review was to establish how quality of life (QoL) is affected in idiopathic focal, multifocal and segmental dystonia. This review aimed to evaluate variations in QoL between different subtypes of dystonia, identify the determinants of QoL and assess the effects of different treatments on QoL. METHODOLOGY: A systematic computer-based literature search was conducted using the PubMed database to search for papers on QoL in idiopathic focal, segmental, multifocal and generalized dystonia. We identified 75 studies meeting our inclusion criteria. Information was extracted regarding prevalence, demographics and response to treatment where indicated.
resultsThis review revealed QoL to be a significant yet often overlooked issue in idiopathic dystonia. Data consistently showed that dystonia has a negative effect on QoL in patients compared to healthy controls, when measured using disease-specific and generic QoL measures. The majority of studies (n = 25) involved patients with cervical dystonia, followed by benign-essential blepharospasm (n = 10). Along with the beneficial effect to the dystonia symptoms, treatment using Botulinum Toxin and Deep Brain Stimulation is also effective in improving overall QoL across the majority of subtypes.
conclusionThe findings demonstrate that patients' QoL should routinely be assessed and monitored, as this may affect subsequent management. Further research will allow for more robust management of factors contributing to impaired QoL, aside from the physical defects found in dystonia.
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