Evidence map›Paper›PMID 30460443›Full record

ArticleJournal of thrombosis and thrombolysis2019

Adjusted versus actual body weight dosing of 4-factor prothrombin complex concentrate in obese patients with warfarin-associated major bleeding.

Keaton S Smetana, Rachel Ziemba, Casey C May, Michael J Erdman, Edward T Van Matre, G Morgan Jones

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keaton S SmetanaDepartment of Pharmacy, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, Doan Hall Room 368, Columbus, OH, 43210, USA. Keaton.Smetana@osumc.edu.
Rachel ZiembaThe Ohio State University College of Pharmacy, 500 W 12th Ave, Columbus, OH, 43210, USA.
Casey C MayDepartment of Pharmacy, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, Doan Hall Room 368, Columbus, OH, 43210, USA.
Michael J ErdmanDepartment of Pharmacy, University of Florida Health, 655 West 8th Street, Jacksonville, FL, 32209, USA.
Edward T Van MatreDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, 881 Madison Avenue, Memphis, TN, 38163, USA.
G Morgan JonesDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, 881 Madison Avenue, Memphis, TN, 38163, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The package insert of 4-factor prothrombin complex concentrate (4F-PCC) contains specific dosing recommendations stating to determine the patients dose based on their INR and weight, capping the weight at 100 kg. However, the mean body mass index (BMI) in the 4F-PCC U.S. approval study was 27 kg/m

Indexed as

Drug Dosage CalculationsObesityAdultAgedAged, 80 and overBlood Coagulation FactorsBody Mass IndexBody WeightFemaleHemorrhageHumansInternational Normalized RatioMaleMiddle AgedRetrospective StudiesTreatment OutcomeBlood Coagulation Factorsprothrombin complex concentratesWarfarinAnticoagulation therapyHematologyHemorrhagic disordersObesityProthrombin

Identifiers

PMID30460443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.