ArticleAnnals of translational medicine2018
Is mechanical power the final word on ventilator-induced lung injury?-no.
Article in Annals of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Mechanical power during one-lung ventilation is associated with postoperative pulmonary complications in patients undergoing lobectomy: a single-center prospective cohort study.BMC anesthesiology · 2026Trial
- Effect of automated versus conventional ventilation on mechanical power of ventilation-A randomized crossover clinical trial.PloS one · 2024Trial
- Mechanical Power as a Predictor of Outcomes During Mechanical Ventilation in Coronavirus Disease 2019 (COVID-19): An Updated Systematic Review.Journal of clinical medicine · 2026Review
- [WAKWiN minireview: intraoperative ventilation and postoperative pulmonary complications-Current evidence and concepts for lung protection].Die Anaesthesiologie · 2026Review
- Bedside Assessment of PEEP-Induced Volume and Mechanical Power in Mechanically Ventilated Adults Without ARDS: A Post Hoc Analysis.Medical sciences (Basel, Switzerland) · 2026Article
- When mechanical power remains high despite conventional lung-protective settings: a physiology-driven bedside framework.Annals of intensive care · 2026Review
- Cyclic stretch increases glucose uptake and pro-inflammatory response in rat alveolar epithelial type II cells.Frontiers in physiology · 2026Article
- Mechanical Power and Driving Pressure: Mechanisms of Lung Injury, Markers of Pathophysiology, or Therapeutic Targets?Journal of clinical medicine · 2025Article
- Overpowered or Underexplored: Is Mechanical Power Causative or Reflective of Outcomes in the ICU?Chest · 2025Article
- Mechanical Power: Using Ideal Body Weight to Identify Injurious Mechanical Ventilation Thresholds.Respiratory care · 2025Review
- Effects of secular changes in tidal volume and respiratory rate on the mechanical power of ventilation: a retrospective single-center study of invasively ventilated patients.Critical care science · 2025Article
- Effects of prone positioning on lung mechanical power components in patients with acute respiratory distress syndrome: a physiologic study.Critical care (London, England) · 2024Article
- Mechanical power is associated with cardiac output and pulmonary blood flow in an experimental acute respiratory distress syndrome in pigs.Frontiers in physiology · 2024Article
- Individualized positive end-expiratory pressure reduces driving pressure in obese patients during laparoscopic surgery under pneumoperitoneum: a randomized clinical trial.Frontiers in physiology · 2024Article
- Understanding the mechanisms of ventilator-induced lung injury using animal models.Intensive care medicine experimental · 2023Review
- The Impact of Mechanical Energy Assessment on Mechanical Ventilation: A Comprehensive Review and Practical Application.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Management of severe acute respiratory distress syndrome: a primer.Critical care (London, England) · 2023Review
- Personalized Respiratory Support in ARDS: A Physiology-to-Bedside Review.Journal of clinical medicine · 2023Review
- Effects of obesity, pneumoperitoneum, and body position on mechanical power of intraoperative ventilation: an observational study.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Observational
- Mechanical power: meaning, uses and limitations.Intensive care medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite being a promising idea that combines several variables related to ventilator-induced lung injury (VILI), the concept of mechanical power (MP) carries a number of limitations, leaves several open questions, lacks proper modelling of positive end-expiratory pressure (PEEP) effects and, more importantly, does not respect the amount of lung tissue subjected to MP. First, the assessment of MP as a measure for development of VILI would have the highest relevance when volume displacement and related pressure changes are measured directly within the lung. Thus, ideally the relationship between MP delivered to the total respiratory system, and that delivered to lung tissue is discerned. Second, MP as defined today relates to the inspiratory phase only, and it is very possible that the expiratory phase will also play a role. Third, the calculation of MP during spontaneous breathing is challenging as airway pressure, flow and esophageal pressure are affected counter-directionally and simultaneously overlapping by the action of the ventilator and the respiratory muscles. Fourth, in its current form, MP is modelled with a positive linear relationship with PEEP, which is based on incorrect mathematical modelling to integrate the role of PEEP into MP. Fifth, the present equation used to calculate MP is qualitatively in disagreement with clinical data on VILI. The reduction of MP to its elastic part, might not only result in a higher association with VILI, but also amplifies an indirect U-shaped relationship with PEEP.
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