ReviewAnnals of translational medicine2018
Assessing breathing effort in mechanical ventilation: physiology and clinical implications.
Review in Annals of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Problems of Measurement and Evaluation of Breathing Effort in Spontaneously Breathing Subjects
Analysis of Advanced Physiological Ventilatory Parameters During Spontaneous Breathing Effort in Patients with Acute Hypoxemic Respiratory Failure
Impact of Immersive Virtual Reality (IVR) on Respiratory Effort: A Pilot Study in Healthy Adults
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acquisition of respiratory surface EMG: a systematic literature review of electrode configurations and methodological reporting.Critical care (London, England) · 2025Pooled it
- Effects of four weeks of inspiratory muscle training with different resistance modalities on pulmonary function and specialized athletic ability in synchronized swimmers: a randomised trial.Scientific reports · 2026Trial
- Effect of automated versus conventional ventilation on mechanical power of ventilation-A randomized crossover clinical trial.PloS one · 2024Trial
- Effect of pediatric ventilation weaning technique on work of breathing.Respiratory research · 2022Trial
- Physiological Effects of High-Flow Tracheal Oxygen vs. Pressure Support Ventilation in Neurosurgical Patients with Brain Tumors Facing Delayed Extubation: A Pilot Study.Neurocritical care · 2026Article
- Patient Self-Inflicted Lung Injury in ARDS: From Physiological Concept to Clinical Syndrome.Journal of clinical medicine · 2026Review
- Continuous and noninvasive respiratory effort monitoring: a narrative review of emerging techniques.Journal of intensive care · 2026Review
- Monitoring diaphragmatic effort during diaphragm neurostimulation-assisted ventilation.Critical care (London, England) · 2025Article
- Application of neurally adjusted ventilatory assist (NAVA): a narrative review.Journal of thoracic disease · 2025Review
- Electromyographic Diaphragm and Electrocardiographic Signal Analysis for Weaning Outcome Classification in Mechanically Ventilated Patients.Sensors (Basel, Switzerland) · 2025Article
- Assessing inspiratory drive and effort in critically ill patients at the bedside.Critical care (London, England) · 2025Review
- Diaphragmatic ultrasound and its relationship to breathing effort and load: a prospective observational study.Critical care (London, England) · 2025Observational
- Debate on the Role of Eccentric Contraction of the Diaphragm: Is It Always Harmful?Healthcare (Basel, Switzerland) · 2025Article
- Patient-Self Inflicted Lung Injury (P-SILI): An Insight into the Pathophysiology of Lung Injury and Management.Journal of clinical medicine · 2025Review
- Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Coexistence: From Pathophysiology to Clinical Complications.International journal of chronic obstructive pulmonary disease · 2025Review
- Assessing agreement among non-invasive indicators for inspiratory effort during pressure support ventilation.Frontiers in medicine · 2025Article
- Bedside Assessment of the Respiratory System During Invasive Mechanical Ventilation.Journal of clinical medicine · 2024Review
- Ventilator performances for non-invasive ventilation: a bench study.BMJ open respiratory research · 2024Article
- Respiratory muscle dysfunction in acute and chronic respiratory failure: how to diagnose and how to treat?European respiratory review : an official journal of the European Respiratory Society · 2024Review
- The Relationship of Diaphragmatic Ultrasound-Based and Manometric Indices With Difficult Weaning in Tracheostomized Patients.Respiratory care · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have shown both beneficial and detrimental effects of patient breathing effort in mechanical ventilation. Quantification of breathing effort may allow the clinician to titrate ventilator support to physiological levels of respiratory muscle activity. In this review we will describe the physiological background and methodological issues of the most frequently used methods to quantify breathing effort, including esophageal pressure measurement, the work of breathing, the pressure-time-product, electromyography and ultrasound. We will also discuss the level of breathing effort that may be considered optimal during mechanical ventilation at different stages of critical illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.