ReviewAnnals of translational medicine2018
Respiratory mechanics in patients with acute respiratory distress syndrome.
Review in Annals of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy.Critical care (London, England) · 2023Trial
- Diet-induced obesity alleviates epithelial damage in hyperoxic acute lung injury (HALI) in mice.Respiratory research · 2026Article
- Beyond One-Size-Fits-All: Precision Mechanical Ventilation in ARDS.Journal of clinical medicine · 2026Review
- When mechanical power remains high despite conventional lung-protective settings: a physiology-driven bedside framework.Annals of intensive care · 2026Review
- Assessment of Respiratory Mechanics and Inspiratory Effort During Spontaneous Breathing Trials to Predict Extubation Failure in High-Risk Patients.American journal of respiratory and critical care medicine · 2025Article
- Driving pressure in acute respiratory distress syndrome for developing a protective lung strategy: A systematic review.World journal of critical care medicine · 2025Article
- New experiments and models to describe soluble surfactant adsorption above and below the critical micelle concentration.Journal of colloid and interface science · 2025Article
- Article
- The accuracy of simplified calculation of mechanical power: a simulation study.Journal of thoracic disease · 2023Article
- Exogenous surfactant reduces inflammation and redox imbalance in rats under prone or supine mechanical ventilation.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Gastric Aspiration and Ventilator-Induced Model of Acute Respiratory Distress Syndrome in Swine.The Journal of surgical research · 2022Article
- Lung function improves after delayed treatment with CNP-miR146a following acute lung injury.Nanomedicine : nanotechnology, biology, and medicine · 2022Article
- Interpretation and use of intraoperative protective ventilation parameters: a scoping review.Anaesthesiology intensive therapy · 2022Article
- Respiratory Mechanics in a Cohort of Critically Ill Subjects With COVID-19 Infection.Respiratory care · 2021Article
- [Research advances on the mechanisms and prevention and treatment of patient self-inflicted lung injury].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Review
- Emodin Inhibits Lipopolysaccharide-Induced Inflammation by Activating Autophagy in RAW 264.7 Cells.Chinese journal of integrative medicine · 2021Article
- Hypercapnia in the critically ill: insights from the bench to the bedside.Interface focus · 2021Review
- Direction and Magnitude of Change in Plateau From Peak Pressure During Inspiratory Holds Can Identify the Degree of Spontaneous Effort and Elastic Workload in Ventilated Patients.Critical care medicine · 2021Article
- A research update: Significance of cytokine storm and diaphragm in COVID-19.Current research in pharmacology and drug discovery · 2021Article
- Inhibition of IP3R/Ca2+ Dysregulation Protects Mice From Ventilator-Induced Lung InjuryFrontiers in immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the recognition of its iatrogenic potential, mechanical ventilation remains the mainstay of respiratory support for patients with acute respiratory distress syndrome (ARDS). The low volume ventilation has been recognized as the only method to reduce mortality of ARDS patients and plateau pressure as the lighthouse for delivering safe ventilation. Recent investigations suggest that a ventilation based on lung mechanics (tidal ventilation tailored to the available lung volume able to receive it, i.e., driving pressure) is a successful approach to improve outcome. However, currently available bedside mechanical variables do not consider regional mechanical properties of ARDS affected lungs, which include the role of local stress risers at the boundaries of areas with different aeration. A unifying approach considers lung-related causes and ventilation-related causes of lung injury. These last may be incorporated in the mechanical power (i.e., amount of mechanical energy transferred per unit of time). Ventilation-induced lung injury (which includes the self-inflicted lung injury of a spontaneously breathing patient) can therefore be prevented by the adoption of measures promoting an increase of ventilable lung and its homogeneity and by delivering lower levels of mechanical power. Prone position promotes lung homogeneity without increasing the delivered mechanical power. This review describes the recent developments on respiratory mechanics in ARDS patients, providing both bedside and research insights from the most updated evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.