Evidence map›Paper›PMID 30460213›Full record

ReviewFrontiers in pediatrics2018

Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development.

Hanna Lee, Emily Padhi, Yu Hasegawa, Jules Larke, Mariana Parenti, Aidong Wang, Olle Hernell, Bo Lönnerdal, Carolyn Slupsky

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 224 citations in OpenAlex.

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  15. A Framework for Evaluation of New Processing Technologies in Human Milk Banking.Comprehensive reviews in food science and food safety · 2025
    Review
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hanna LeeDepartment of Food Science and Technology, University of California, Davis, Davis, CA, United States.
Emily PadhiDepartment of Food Science and Technology, University of California, Davis, Davis, CA, United States.
Yu HasegawaDepartment of Food Science and Technology, University of California, Davis, Davis, CA, United States.
Jules LarkeDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Mariana ParentiDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Aidong WangDepartment of Food Science and Technology, University of California, Davis, Davis, CA, United States.
Olle HernellDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Bo LönnerdalDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Carolyn SlupskyDepartment of Food Science and Technology, University of California, Davis, Davis, CA, United States.
University of California, Davis · USUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human milk is uniquely optimized for the needs of the developing infant. Its composition is complex and dynamic, driven primarily by maternal genetics, and to a lesser extent by diet and environment. One important component that is gaining attention is the milk fat globule (MFG). The MFG is composed of a triglyceride-rich core surrounded by a tri-layer membrane, also known as the milk fat globule membrane (MFGM) that originates from mammary gland epithelia. The MFGM is enriched with glycerophospholipids, sphingolipids, cholesterol, and proteins, some of which are glycosylated, and are known to exert numerous biological roles. Mounting evidence suggests that the structure of the MFG and bioactive components of the MFGM may benefit the infant by aiding in the structural and functional maturation of the gut through the provision of essential nutrients and/or regulating various cellular events during infant growth and immune education. Further, antimicrobial peptides and surface carbohydrate moieties surrounding the MFG might have a pivotal role in shaping gut microbial populations, which in turn may promote protection against immune and inflammatory diseases early in life. This review seeks to: (1) understand the components of the MFG, as well as maternal factors including genetic and lifestyle factors that influence its characteristics; (2) examine the potential role of this milk component on the intestinal immune system; and (3) delineate the mechanistic roles of the MFG in infant intestinal maturation and establishment of the microbiota in the alimentary canal.

Indexed as

gut maturationimmune systeminfant developmentmicrobiotamilk fat globulemilk fat globule membrane

Identifiers

PMID30460213
PMCPMC6232911
OpenAlexW2898335287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.