ArticleFrontiers in cellular and infection microbiology2018
H5N1 Influenza a Virus Replicates Productively in Pancreatic Cells and Induces Apoptosis and Pro-Inflammatory Cytokine Response.
Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 39 citations in OpenAlex.
- Comprehensive pathological, immunohistochemical, and apoptotic analysis of the highly pathogenic avian influenza a virus H5N1 clade 2.3.4.4b in poultry in Taiwan.Poultry science · 2026Article
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- Computational identification of novel therapeutic candidates for Streptococcus pyogenes and influenza A coinfections through transcriptomic-based drug repositioning.BMC microbiology · 2026Article
- SREBP2-dependent lipid droplet formation enhances viral replication and deteriorates lung injury in mice following IAV infection.Emerging microbes & infections · 2025Article
- Design and Efficacy of Oncolytic Viruses and Antitumor Vaccines: A Dead End in the Immunotherapy of Pancreatic Cancer?International journal of molecular sciences · 2025Review
- Vital Role of PINK1/Parkin-Mediated Mitophagy of Pulmonary Epithelial Cells in Severe Pneumonia Induced by IAV and SecondaryInternational journal of molecular sciences · 2025Article
- Hospitalized children with influenza A before, during and after COVID-19 pandemic: a retrospective cohort study.BMC pediatrics · 2024Article
- Acute hemorrhagic pancreatitis following influenza infection: a case report.Journal of medical case reports · 2023Article
- Melatonin alleviates lung injury in H1N1-infected mice by mast cell inactivation and cytokine storm suppression.PLoS pathogens · 2023Article
- Seneca Valley virus induces proinflammatory cytokine and chemokine responseCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- The possible role of viral infections in acute pancreatitis: a review of literature.Gastroenterology and hepatology from bed to bench · 2023Review
- PHEVIR: an artificial intelligence algorithm that predicts the molecular role of pathogens in complex human diseases.Scientific reports · 2022Article
- COVID-19 and diabetes in children.Annals of pediatric endocrinology & metabolism · 2022Article
- Transcriptomic Profiling of Mouse Mast Cells upon Pathogenic Avian H5N1 and Pandemic H1N1 Influenza a Virus Infection.Viruses · 2022Article
- Dual RNA-Seq of H5N1 Avian Influenza Virus and Host Cell Transcriptomes Reveals Novel Insights Into Host-Pathogen Cross Talk.Frontiers in microbiology · 2022Article
- Antiviral Activity of 3D, a Butene Lactone Derivative Against Influenza A Virus In Vitro and In Vivo.Viruses · 2021Article
- Potential of H1N1 influenza A virus as an air borne pathogen to induce infectivity in pancreas: a mouse model study.Journal of environmental health science & engineering · 2020Article
- Derivation of induced pluripotent stem cells from ferret somatic cells.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Acute Pancreatitis Caused by Complications of Influenza A in the Setting of Chronic Lymphocytic Leukemia.Cureus · 2020Article
- Safety, Immunogenicity, and Effectiveness of Defective Viral Particles Arising in Mast Cells Against Influenza in Mice.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inflammatory response and apoptosis have been proved to have a crucial role in the pathogenesis of the influenza A virus (IAV). Previous studies indicated that while IAV commonly causes pancreatitis and pancreatic damage in naturally and experimentally infected animals, the molecular mechanisms of the pathogenesis of IAV infection are less reported. In the present study, we showed for the first time that both avian-like (α-2,3-linked) and human-like (α-2,6-linked) sialic acid (SA) receptors were expressed by the mouse pancreatic cancer cell line PAN02 and the human pancreatic cancer cell line PANC-1. Using growth kinetics experiments, we also showed that PAN02 and PANC-1 cells supported the productive replication of the H5N1 highly pathogenic avian influenza while exhibited the limited replication of IAV subtypes H1N1 and H7N2
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