Evidence map›Paper›PMID 30460158›Full record

ArticleBiomedical optics express2018

Small separation diffuse correlation spectroscopy for measurement of cerebral blood flow in rodents.

Eashani Sathialingam, Seung Yup Lee, Bharat Sanders, Jaekeun Park, Courtney E McCracken, Leah Bryan, Erin M Buckley

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Eashani SathialingamWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Seung Yup LeeWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Bharat SandersWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Jaekeun ParkWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Courtney E McCrackenDepartment of Pediatrics, School of Medicine, Emory University, 2015 Uppergate Dr., Atlanta, GA 30322, USA.
Leah BryanDepartment of Pediatrics, School of Medicine, Emory University, 2015 Uppergate Dr., Atlanta, GA 30322, USA.
Erin M BuckleyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Georgia Institute of Technology · USEmory University · US

Funding

Objective biomarkers of cognitive outcome in repetitive mild traumatic brain injuryR21NS104801 · NINDS · EMORY UNIVERSITY · PI BUCKLEY, ERIN MCGUIRE · 2018 to 2019
$425k
Microvascular Cerebral Blood Flow Measured with Diffuse Correlation Spectroscopy in Children with Sickle Cell DiseaseR21HL138062 · NHLBI · EMORY UNIVERSITY · PI BUCKLEY, ERIN MCGUIRE · 2017 to 2018
$420k
NHLBI NIH HHS R21 HL138062NINDS NIH HHS R21 NS104801
6 · The paper itself

Abstract

Diffuse correlation spectroscopy (DCS) has shown promise as a means to non-invasively measure cerebral blood flow in small animal models. Here, we characterize the validity of DCS at small source-detector reflectance separations needed for small animal measurements. Through Monte Carlo simulations and liquid phantom experiments, we show that DCS error increases as separation decreases, although error remains below 12% for separations > 0.2 cm. In mice, DCS measures of cerebral blood flow have excellent intra-user repeatability and strongly correlate with MRI measures of blood flow (R = 0.74,

Identifiers

PMID30460158
PMCPMC6238900
OpenAlexW2898295258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.