ArticleBiomedical optics express2018
Light propagation and capture in cone photoreceptors.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- In Vivo Human Cone Photoreceptor Inner Segment Diameter Database Using Adaptive Optics Retinal Imaging.Investigative ophthalmology & visual science · 2026Article
- Physiological basis of resolution acuity in vision.Nature communications · 2026Article
- Mimicking the retinal neuron functions by a photoresponsive single transistor with a double gate.Biophysical journal · 2024Article
- Design of Lidar Receiving Optical System with Large FoV and High Concentration of Light to Resist Background Light Interference.Micromachines · 2024Article
- Using high-resolution microscopy data to generate realistic structures for electromagnetic FDTD simulations from complex biological models.Nature protocols · 2024Article
- Human cone elongation responses can be explained by photoactivated cone opsin and membrane swelling and osmotic response to phosphate produced by RGS9-catalyzed GTPase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mitochondria in cone photoreceptors act as microlenses to enhance photon delivery and confer directional sensitivity to light.Science advances · 2022Article
- Patches of Dysflective Cones in Eyes With No Known Disease.Investigative ophthalmology & visual science · 2022Article
- Cone photoreceptor reflectance variation in the northern tree shrew and thirteen-lined ground squirrel.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Subjective measurement of the Stiles-Crawford effect with different field sizes.Biomedical optics express · 2021Article
- The Relationship Between Visual Sensitivity and Eccentricity, Cone Density and Outer Segment Length in the Human Foveola.Investigative ophthalmology & visual science · 2021Article
- Article
- Light reflectivity and interference in cone photoreceptors.Biomedical optics express · 2019Article
- Directional light-capture efficiency of the foveal and parafoveal photoreceptors at different luminance levels: an experimental and analytical study.Biomedical optics express · 2019Article
- Article
- Article
- Spatial summation of individual cones in human color vision.PloS one · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The light capturing properties of cone photoreceptors create the elementary signals that form the basis of vision. Variation in the amplitude of individual cone signals has been found physiologically as part of normal retinal circuit processing. Less well characterized is how cone signals may vary due to purely optical properties. We present a model of light propagation in cones using a finite difference beam propagation method to simulate how light from a small stimulus travels through a cone plus its immediate neighbors. The model calculates the amount of light absorbed in the cone outer segments, from which an estimate of the photoresponse can be made. We apply the method to adaptive optics microstimulation to find the optimum optical conditions that will confine the most light into a single cone in the human retina. We found that light capture is especially sensitive to beam size at the pupil and to the cone diameter itself, with the two factors having a complex relationship leading to sizable variation in light capture. Model predictions were validated with two types of psychophysical data. The model can be employed with arbitrary stimuli and photoreceptor parameters, making it a useful tool for studying photoreceptor function in normal or diseased conditions.
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Registered trials
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