Evidence map›Paper›PMID 30459945›Full record

ArticleAntimicrobial resistance and infection control2018

The importance of adjusting for enterococcus species when assessing the burden of vancomycin resistance: a cohort study including over 1000 cases of enterococcal bloodstream infections.

Tobias Siegfried Kramer, Cornelius Remschmidt, Sven Werner, Michael Behnke, Frank Schwab, Guido Werner, Petra Gastmeier, Rasmus Leistner

Open access · goldAbstract read
In one paragraph

Article in Antimicrobial resistance and infection control, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 5 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Clinical epidemiology and case fatality due to antimicrobial resistance in Germany: a systematic review and meta-analysis, 1 January 2010 to 31 December 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Pooled it
  2. Hospital-acquired infections caused by enterococci: a systematic review and meta-analysis, WHO European Region, 1 January 2010 to 4 February 2020.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tobias Siegfried Kramer1Charité Universitätsmedizin Berlin, Institute of Hygiene and Environmental Medicine, Berlin, Germany.ORCID 0000-0002-2728-9399
Cornelius Remschmidt1Charité Universitätsmedizin Berlin, Institute of Hygiene and Environmental Medicine, Berlin, Germany.
Sven Werner3Department of Medical and Financial Controlling, Charité Universitätsmedizin Berlin, Berlin, Germany.
Michael Behnke1Charité Universitätsmedizin Berlin, Institute of Hygiene and Environmental Medicine, Berlin, Germany.
Frank Schwab1Charité Universitätsmedizin Berlin, Institute of Hygiene and Environmental Medicine, Berlin, Germany.
Guido Werner4Robert Koch Institute, FG13 Nosocomial Pathogens and Antibiotic Resistance, Wernigerode, Germany.
Petra Gastmeier1Charité Universitätsmedizin Berlin, Institute of Hygiene and Environmental Medicine, Berlin, Germany.
Rasmus Leistner1Charité Universitätsmedizin Berlin, Institute of Hygiene and Environmental Medicine, Berlin, Germany.
Institut für Hygiene und Umwelt · DECharité - Universitätsmedizin Berlin · DERobert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Infections caused by vancomycin-resistant enterococci (VRE) are on the rise worldwide. Few studies have tried to estimate the mortality burden as well as the financial burden of those infections and found that VRE are associated with increased mortality and higher hospital costs. However, it is unclear whether these worse outcomes are attributable to vancomycin resistance only or whether the enterococcal species ( Methods: We conducted a retrospective cohort study on patients with BSI caused by Results: Overall, we identified 1160 consecutive cases of BSI caused by enterococci: 596 (51.4%) cases of Conclusion: Our data indicates that in-hospital mortality and infection-attributed hospital stay in enterococci BSI might rather be influenced by Enterococcus species and underlying diseases than by vancomycin resistance. Therefore, future studies should consider adjusting for Enterococcus species in addition to vancomycin resistance in order to provide a conservative estimate for the burden of VRE infections.

Indexed as

Vancomycin ResistanceAgedAnti-Bacterial AgentsBacteremiaEnterococcus faecalisEnterococcus faeciumFemaleGram-Positive Bacterial InfectionsHospital CostsHumansLength of StayMaleMiddle AgedRetrospective StudiesVancomycinVancomycin-Resistant EnterococciAnti-Bacterial AgentsVancomycinBloodstream infectionEnterococcus faeciumVancomycin-resistant enterococci

Identifiers

PMID30459945
PMCPMC6234683
OpenAlexW2901491938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.