Evidence map›Paper›PMID 30459931›Full record

ArticleOncotarget2018

NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development.

Ian P Harrison, Antony Vinh, Ian R D Johnson, Raymond Luong, Grant R Drummond, Christopher G Sobey, Tony Tiganis, Elizabeth D Williams, John J O' Leary, Doug A Brooks and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Human Group IIA Secreted Phospholipase AInternational journal of molecular sciences · 2026
    Review
  2. The Oxidative Stress: Origin and Role in Aging and Diseases.Antioxidants (Basel, Switzerland) · 2026
    Review
  3. Article
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  14. Article
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  18. Implications of Altered Endosome and Lysosome Biology in Space Environments.International journal of molecular sciences · 2020
    Review
  19. The Role of Epac in Cancer Progression.International journal of molecular sciences · 2020
    Review
  20. Inhibiting the Activity of NADPH Oxidase in Cancer.Antioxidants & redox signaling · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Ian P HarrisonInfection and Immunity Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Melbourne, Victoria 3800, Australia.
Antony VinhDepartment of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, Victoria 3086, Australia.
Ian R D JohnsonSchool of Pharmacy and Medical Sciences, University of South Australia Cancer Research Institute, University of South Australia, Adelaide, South Australia 5001, Australia.
Raymond LuongInfection and Immunity Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Melbourne, Victoria 3800, Australia.
Grant R DrummondDepartment of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, Victoria 3086, Australia.
Christopher G SobeyDepartment of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, Victoria 3086, Australia.
Tony TiganisMetabolic Disease and Obesity Program, Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.
Elizabeth D WilliamsAustralian Prostate Cancer Research Centre-Queensland, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Resea rch Institute, Brisbane, Queensland 4000, Australia.
John J O' LearyHistopathology, School of Medicine Trinity College Dublin, Ireland, Sir Patrick Dun's Laboratory, Central Pathology Laboratory, St James's Hospital, Dublin 8, Ireland.
Doug A BrooksSchool of Pharmacy and Medical Sciences, University of South Australia Cancer Research Institute, University of South Australia, Adelaide, South Australia 5001, Australia.
Stavros SelemidisInfection and Immunity Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Melbourne, Victoria 3800, Australia.
La Trobe University · AUAustralian Regenerative Medicine Institute · AUCoombe Women & Infants University Hospital · IEMonash University · AURMIT University · AUSt. James's Hospital · IETranslational Research Institute · AUUniversity of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) promote growth factor signalling including for VEGF-A and have potent angiogenic and tumourigenic properties. However, the precise enzymatic source of ROS generation, the subcellular localization of ROS production and cellular targets

Indexed as

endosomeNADPH oxidaseNOX2prostate cancerreactive oxygen species

Identifiers

PMID30459931
PMCPMC6226044
OpenAlexW2897877092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.