ArticleFrontiers in microbiology2018
Hydroxytyrosol (HT) Analogs Act as Potent Antifungals by Direct Disruption of the Fungal Cell Membrane.
Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- A comprehensive review ofRSC advances · 2026Review
- Novel hydroxytyrosol esters as potential anti-amyloid and neuroprotective agents for Alzheimer's disease.RSC medicinal chemistry · 2026Article
- Exploring olive mill wastewater as a reservoir of antimicrobial and antioxidant compounds: insights from a cross-regional Moroccan study.Frontiers in microbiology · 2026Article
- Fermented Fruits, Vegetables, and Legumes in Metabolic Syndrome: From Traditional Use to Functional Foods and Medical Applications.Nutrients · 2025Review
- Hydroxytyrosol: biological activities and potential application in livestock production.Frontiers in veterinary science · 2025Review
- Towards New Scaffolds for Antimicrobial Activity-In Silico/In Vitro Workflow Introducing New Lead Compounds.Antibiotics (Basel, Switzerland) · 2024Article
- Hydroxytyrosol isolation, comparison of synthetic routes and potential biological activities.Food science & nutrition · 2024Review
- Protective Effect of Treated Olive Mill Wastewater on Target Bacteria and Mitochondrial Voltage-Dependent Anion-Selective Channel 1.Antioxidants (Basel, Switzerland) · 2023Article
- Almond [Molecules (Basel, Switzerland) · 2023Article
- Olive Tree Derivatives and Hydroxytyrosol: Their Potential Effects on Human Health and Its Use as Functional Ingredient in Meat.Foods (Basel, Switzerland) · 2021Review
- Green Synthesis of Zinc Oxide Nanoparticles UsingBiology · 2021Article
- Chemical Composition and Antimicrobial Activity of a New Olive Pomace Functional Ingredient.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing.Foods (Basel, Switzerland) · 2021Review
- Impact of Membrane Lipids on UapA and AzgA Transporter Subcellular Localization and Activity inJournal of fungi (Basel, Switzerland) · 2021Article
- NaturalFoods (Basel, Switzerland) · 2021Article
- Olive Mill Wastes: A Source of Bioactive Molecules for Plant Growth and Protection against Pathogens.Biology · 2020Review
- Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health.Molecules (Basel, Switzerland) · 2019Review
- Hydroxytyrosol (HT) Analogs Act as Potent Antifungals by Direct Disruption of the Fungal Cell Membrane.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal infections constitute an emerging threat and a prevalent health problem due to increasing number of immunocompromised people and pharmacological or other treatments aiming at viral infections, cancer or allergies. Currently used antifungals suffer from inefficiency, toxic side effects and developing drug-resistance. Additionally, over the last two decades no new classes of antifungals have been approved, emphasizing the urgent need for developing a novel generation of antifungals. Here, we investigate the antifungal activity of a series of chemically synthesized Hydroxytyrosol (HT) analogs. HT is one of the major phenolic compounds in olive oil, shown to possess radical-scavenging antioxidant, antiproliferative, proapoptotic and anti-inflammatory activities. No previous report has studied HT analogs as antifungals. We show that specific analogs have broad and strong antifungal activity, significantly stronger than the parent compound HT. Using
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.