ArticleFrontiers in physiology2018
Plasticity in the Sensitivity to Light in Aging: Decreased Non-visual Impact of Light on Cognitive Brain Activity in Older Individuals but No Impact of Lens Replacement.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Cortical excitability is affected by light exposure - Distinct effects in adolescents and young adults.Neurobiology of sleep and circadian rhythms · 2026Article
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- Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers.Nature communications · 2024Article
- Blue Light and Digital Screens Revisited: A New Look at Blue Light from the Vision Quality, Circadian Rhythm and Cognitive Functions Perspective.Journal of biomedical physics & engineering · 2024Review
- The cognitive impact of light: illuminating ipRGC circuit mechanisms.Nature reviews. Neuroscience · 2024Review
- Light as a Modulator of Non-Image-Forming Brain Functions-Positive and Negative Impacts of Increasing Light Availability.Clocks & sleep · 2023Review
- Luxotonic signals in human prefrontal cortex as a possible substrate for effects of light on mood and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Age-related neuroendocrine and alerting responses to light.GeroScience · 2021Article
- In search of blue-light effects on cognitive control.Scientific reports · 2021Article
- Blue-light effects on saccadic eye movements and attentional disengagement.Attention, perception & psychophysics · 2021Article
- Effects of Daytime Electric Light Exposure on Human Alertness and Higher Cognitive Functions: A Systematic Review.Frontiers in psychology · 2021Review
- Steady-State Pupil Size Varies with Circadian Phase and Sleep Homeostasis in Healthy Young Men.Clocks & sleep · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beyond its essential visual role, light, and particularly blue light, has numerous non-visual effects, including stimulating cognitive functions and alertness. Non-visual effects of light may decrease with aging and contribute to cognitive and sleepiness complaints in aging. However, both the brain and the eye profoundly change in aging. Whether the stimulating effects light on cognitive brain functions varies in aging and how ocular changes may be involved is not established. We compared the impact of blue and orange lights on non-visual cognitive brain activity in younger (23.6 ± 2.5 years), and older individuals with their natural lenses (NL; 66.7 ± 5.1 years) or with intraocular lens (IOL) replacement following cataract surgery (69.6 ± 4.9 years). Analyses reveal that blue light modulates executive brain responses in both young and older individuals. Light effects were, however, stronger in young individuals including in the hippocampus and frontal and cingular cortices. Light effects did not significantly differ between older-IOL and older-NL while regression analyses indicated that differential brain engagement was not underlying age-related differences in light effects. These findings show that, although its impact decreases, light can stimulate cognitive brain activity in aging. Since lens replacement did not affect light impact, the brain seems to adapt to the progressive decrease in retinal light exposure in aging.
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Registered trials
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