ArticleScientific reports2018
Transcriptomic analysis of Bifidobacterium longum subsp. longum BBMN68 in response to oxidative shock.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
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- Proteomic Analysis ofFoods (Basel, Switzerland) · 2025Article
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- Key Stress Response Mechanisms of Probiotics During Their Journey Through the Digestive System: A Review.Probiotics and antimicrobial proteins · 2023Review
- Oxidative Stress Response of Probiotic StrainFoods (Basel, Switzerland) · 2023Article
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- Novel Insights into the Molecular Mechanisms Underlying Robustness and Stability in Probiotic Bifidobacteria.Applied and environmental microbiology · 2023Article
- The Pleiotropic Effects of Carbohydrate-Mediated Growth Rate Modifications inMicroorganisms · 2023Article
- The secondary metabolite hydrogen cyanide protectsFrontiers in microbiology · 2023Article
- Stress Response in Bifidobacteria.Microbiology and molecular biology reviews : MMBR · 2022Review
- The Gene Expression Profile Differs in Growth Phases of theMicroorganisms · 2022Article
- Genome-Wide Assessment of Stress-Associated Genes in Bifidobacteria.Applied and environmental microbiology · 2022Article
- Bistable auto-aggregation phenotype in Lactiplantibacillus plantarum emerges after cultivation in in vitro colonic microbiota.BMC microbiology · 2021Article
- Integration of Transcriptome and Metabolome Reveals the Genes and Metabolites Involved inInternational journal of molecular sciences · 2021Article
- Transcriptome Analysis Reveals the Genes Involved inMicroorganisms · 2021Article
- The genus bifidobacterium: From genomics to functionality of an important component of the mammalian gut microbiota running title: Bifidobacterial adaptation to and interaction with the host.Computational and structural biotechnology journal · 2021Review
- Bifidobacterium Longum: Protection against Inflammatory Bowel Disease.Journal of immunology research · 2021Review
- Gene Networks Underlying the Resistance ofFrontiers in immunology · 2020Article
- Effects of Linoleic Acid on Gut-DerivedMicroorganisms · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Bifidobacterium longum strain BBMN68 is sensitive to low concentrations of oxygen. A transcriptomic study was performed to identify candidate genes for B. longum BBMN68's response to oxygen treatment (3%, v/v). Expression of genes and pathways of B. longum BBMN68 involved in nucleotide metabolism, amino acid transport, protein turnover and chaperones increased, and that of carbohydrate metabolism, translation and biogenesis decreased to adapt to the oxidative stress. Notably, expression of two classes of ribonucleotide reductase (RNR), which are important for deoxyribonucleotide biosynthesis, was rapidly and persistently induced. First, the class Ib RNR NrdHIEF was immediately upregulated after 5 min oxygen exposure, followed by the class III RNR NrdDG, which was upregulated after 20 min of exposure. The upregulated expression of branched-chain amino acids and tetrahydrofolate biosynthesis-related genes occurred in bifidobacteria in response to oxidative stress. These change toward to compensate for DNA and protein damaged by reactive oxygen species (ROS). In addition, oxidative stress resulted in improved B. longum BBMN68 cell hydrophobicity and autoaggregation. These results provide a rich resource for our understanding of the response mechanisms to oxidative stress in bifidobacteria.
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