Evidence map›Paper›PMID 30459425›Full record

ArticleScientific reports2018

Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers.

Wenlei Ye, Yu-Hsiang Tu, Alexander J Cooper, Zheng Zhang, Vsevolod Katritch, Emily R Liman

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. TRPA1 gene variants hurting our feelings.Pflugers Archiv : European journal of physiology · 2020
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenlei YeDepartment of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA. wenlei.ye@ucsf.edu.ORCID http://orcid.org/0000-0002-4694-1493
Yu-Hsiang TuDepartment of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.
Alexander J CooperDepartment of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.
Zheng ZhangDepartment of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.
Vsevolod KatritchDepartment of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.ORCID http://orcid.org/0000-0003-3883-4505
Emily R LimanDepartment of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA. liman@usc.edu.ORCID http://orcid.org/0000-0003-4765-5496

Funding

Role of the proton channel OTOP1 in taste transductionR01DC013741 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sue C. Kinnamon, EMILY R. LIMAN · 2014 to 2026
$5.7M
Genetic tools to study TRPA1 channel trafficking and distributionR21NS087633 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIMAN, EMILY R. · 2014 to 2015
$452k
NIDCD NIH HHS R01 DC013741NINDS NIH HHS R21 NS087633U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R21NS087633U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC013741
6 · The paper itself

Abstract

The nociceptor ion channel TRPA1 detects a wide range of hazardous chemicals, including reactive electrophiles such as cinnamaldehyde, which gate the channel allowing Na

Indexed as

Ion Channel GatingMutationAcidsAnimalsAspartic AcidCalciumHumansPermeabilityProtein ConformationProtein MultimerizationRatsTRPA1 Cation ChannelZincAcidsAspartic AcidCalciumTRPA1 Cation ChannelZinc

Identifiers

PMID30459425
PMCPMC6244152

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.