Evidence map›Paper›PMID 30459405›Full record

ArticleExperimental & molecular medicine2018

Estrogen receptor β promotes bladder cancer growth and invasion via alteration of miR-92a/DAB2IP signals.

Zhenyu Ou, Yongjie Wang, Jinbo Chen, Le Tao, Li Zuo, Deepak Sahasrabudhe, Jean Joseph, Long Wang, Shuyuan Yeh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental & molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Zhenyu OuDepartments of Urology and Plastic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yongjie WangDepartments of Urology and Plastic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Jinbo ChenDepartments of Urology and Plastic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Le TaoDepartments of Urology and Pathology, University of Rochester Medical Center, Rochester, New York, 14642, USA.
Li ZuoDepartment of Urology, Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, 213003, China.
Deepak SahasrabudheDepartments of Medicine, University of Rochester Medical Center, Rochester, New York, 14642, USA.
Jean JosephDepartments of Urology and Pathology, University of Rochester Medical Center, Rochester, New York, 14642, USA.
Long WangDepartments of Urology and Plastic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China. doctorwanglong@163.com.
Shuyuan YehDepartments of Urology and Pathology, University of Rochester Medical Center, Rochester, New York, 14642, USA. shuyuan_yeh@urmc.rochester.edu.
University of Rochester Medical Center · USCentral South University · CNXiangya Hospital Central South University · CNChangzhou No.2 People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although early studies suggested that bladder cancer (BCa) is more prevalent in men than in women, muscle-invasive rates are higher in women than in men, suggesting that sex hormones might play important roles in different stages of BCa progression. In this work, we found that estrogen receptor beta (ERβ) could increase BCa cell proliferation and invasion via alteration of miR-92a-mediated DAB2IP (DOC-2⁄DAB2 interacting protein) signals and that blocking miR-92a expression with an inhibitor could partially reverse ERβ-enhanced BCa cell growth and invasion. Further mechanism dissection found that ERβ could increase miR-92a expression at the transcriptional level via binding to the estrogen-response-element (ERE) on the 5' promoter region of its host gene C13orf25. The ERβ up-regulated miR-92a could decrease DAB2IP tumor suppressor expression via binding to the miR-92a binding site located on the DAB2IP 3' UTR. Preclinical studies using an in vivo mouse model also confirmed that targeting this newly identified ERβ/miR-92a/DAB2IP signal pathway with small molecules could suppress BCa progression. Together, these results might aid in the development of new therapies via targeting of this ERβ-mediated signal pathway to better suppress BCa progression.

Indexed as

Cell MovementGene Expression Regulation, NeoplasticAnimalsCell Line, TumorCell ProliferationEstrogen Receptor betaFemaleHumansMiceMice, NudeMicroRNAsNeoplasm Invasivenessras GTPase-Activating ProteinsResponse ElementsUrinary Bladder NeoplasmsDab2ip protein, mouseEstrogen Receptor betaMicroRNAsMirn92 microRNA, mouseras GTPase-Activating Proteins

Identifiers

PMID30459405
PMCPMC6243995
OpenAlexW2901043405

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.