ArticleScientific reports2018
Resolving laminar activation in human V1 using ultra-high spatial resolution fMRI at 7T.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Article
- Article
- Imaging joy with generalized slice dithered enhanced resolution and SWAT reconstruction: 3T high spatial-temporal resolution fMRI.Frontiers in neuroimaging · 2025Article
- Real-time fMRI using multi-band echo-volumar imaging with millimeter spatial resolution and sub-second temporal resolution at 3 tesla.Frontiers in neuroscience · 2025Article
- Revealing layer-specific cortical activity in human M1 using high-resolution line-scanning fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Closed-loop fMRI at the mesoscopic scale of columns and layers: Can we do it and why would we want to?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Non-Cartesian 3D-SPARKLING vs Cartesian 3D-EPI encoding schemes for functional Magnetic Resonance Imaging at 7 Tesla.PloS one · 2024Article
- Alpha-180 spin-echo-based line-scanning method for high-resolution laminar-specific fMRI in animals.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Modeling the Visual Landscape: A Review on Approaches, Methods and Techniques.Sensors (Basel, Switzerland) · 2023Review
- Identifying the distinct spectral dynamics of laminar-specific interhemispheric connectivity with bilateral line-scanning fMRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Magnetic resonance imaging at 9.4 T: the Maastricht journey.Magma (New York, N.Y.) · 2023Review
- Sensory eye dominance plasticity in the human adult visual cortex.Frontiers in neuroscience · 2023Article
- Cortical depth-dependent human fMRI of resting-state networks using EPIK.Frontiers in neuroscience · 2023Article
- Do sparse brain activity patterns underlie human cognition?NeuroImage · 2022Article
- Ultrahigh Resolution fMRI at 7T Using Radial-Cartesian TURBINE Sampling.Magnetic resonance in medicine · 2022Article
- Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- A new science of emotion: implications for functional neurological disorder.Brain : a journal of neurology · 2022Review
- Mapping of whole-cerebrum resting-state networks using ultra-high resolution acquisition protocols.Human brain mapping · 2022Article
- Article
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Authors and funding
6 authors.
Funding
Abstract
The mesoscopic organization of the human neocortex is of great interest for cognitive neuroscience. However, fMRI in humans typically maps the functional units of cognitive processing on a macroscopic level. With the advent of ultra-high field MRI (≥7T), it has become possible to acquire fMRI data with sub-millimetre resolution, enabling probing the laminar and columnar circuitry in humans. Currently, laminar BOLD responses are not directly observed but inferred via data analysis, due to coarse spatial resolution of fMRI (e.g. 0.7-0.8 mm isotropic) relative to the extent of histological laminae. In this study, we introduce a novel approach for mapping the cortical BOLD response at the spatial scale of cortical layers and columns at 7T (an unprecedented 0.1 mm, either in the laminar or columnar direction). We demonstrate experimentally and using simulations, the superiority of the novel approach compared to standard approaches for human laminar fMRI in terms of effective spatial resolution in either laminar or columnar direction. In addition, we provide evidence that the laminar BOLD signal profile is not homogeneous even over short patches of cortex. In summary, the proposed novel approach affords the ability to directly study the mesoscopic organization of the human cortex, thus, bridging the gap between human cognitive neuroscience and invasive animal studies.
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