ArticleNature communications2018
Autapses enhance bursting and coincidence detection in neocortical pyramidal cells.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Limit-Cycle Proliferation Under Parametric Delayed Feedback in a Conductance-Based Neuron: Bifurcation Landscape, Orbit Catalog, and Capacity Analysis.Entropy (Basel, Switzerland) · 2026Article
- Article
- Functional Autapses Selectively Form in a Subpopulation of Subicular Pyramidal Cells in Hippocampal Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Deep brain stimulation alleviates Parkinsonian motor deficits through desynchronizing GABA release in mice.Nature communications · 2025Article
- Dynamics and conditions for inhibitory synaptic current to induce bursting and spreading depolarization in pyramidal neurons.Scientific reports · 2025Article
- α4β2The Journal of physiology · 2025Article
- Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection.Pharmacological research · 2025Article
- Biologically inspired heterogeneous learning for accurate, efficient and low-latency neural network.National science review · 2025Article
- Influence of inhibitory autapses on synchronization of inhibitory network gamma oscillations.Cognitive neurodynamics · 2023Article
- Neural waves and short-term memory in a neural net model.Journal of biological physics · 2023Article
- Functional Autapses Form in Striatal Parvalbumin Interneurons but not Medium Spiny Projection Neurons.Neuroscience bulletin · 2023Article
- Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain.Frontiers in synaptic neuroscience · 2023Review
- Control of noise-induced coherent oscillations in three-neuron motifs.Cognitive neurodynamics · 2022Article
- Regimes and mechanisms of transient amplification in abstract and biological neural networks.PLoS computational biology · 2022Article
- Intrinsic bursts facilitate learning of Lévy flight movements in recurrent neural network models.Scientific reports · 2022Article
- NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs.Journal of neuroscience methods · 2022Article
- Bidirectionally Regulating Gamma Oscillations in Wilson-Cowan Model by Self-Feedback Loops: A Computational Study.Frontiers in systems neuroscience · 2022Article
- A Functional Spiking Neural Network of Ultra Compact Neurons.Frontiers in neuroscience · 2021Article
- Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit.Communications biology · 2020Article
- Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autapses are synaptic contacts of a neuron's axon onto its own dendrite and soma. In the neocortex, self-inhibiting autapses in GABAergic interneurons are abundant in number and play critical roles in regulating spike precision and network activity. Here we examine whether the principal glutamatergic pyramidal cells (PCs) also form functional autapses. In patch-clamp recording from both rodent and human PCs, we isolated autaptic responses and found that these occur predominantly in layer-5 PCs projecting to subcortical regions, with very few in those projecting to contralateral prefrontal cortex and layer 2/3 PCs. Moreover, PC autapses persist during development into adulthood. Surprisingly, they produce giant postsynaptic responses (∼5 fold greater than recurrent PC-PC synapses) that are exclusively mediated by AMPA receptors. Upon activation, autapses enhance burst firing, neuronal responsiveness and coincidence detection of synaptic inputs. These findings indicate that PC autapses are functional and represent an important circuit element in the neocortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.