ArticleNature communications2018
Quantitative metaproteomics of medieval dental calculus reveals individual oral health status.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Assessing the Potential of Ancient Protein Sequences in the Study of Hominid Evolution.Genome biology and evolution · 2026Article
- The Demodifier: A tool for screening modification-induced alternate peptide taxonomy in palaeoproteomics.PloS one · 2026Article
- Reconstructing medieval diets through the integration of stable isotope and proteomic analyses from two European burial sites.Scientific reports · 2025Article
- The microbiologist's guide to metaproteomics.iMeta · 2025Review
- Clothomics: a practical guide to understand the opportunities and challenges of omics-based methods in archaeological cloth research.NPJ heritage science · 2025Review
- Automated High-Throughput Biological Sex Identification from Archeological Human Dental Enamel Using Targeted Proteomics.Journal of proteome research · 2024Article
- Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen.iScience · 2024Article
- A Journey into the Evolution of Human Host-Oral Microbiome Relationship through Ancient Dental Calculus: A Scoping Review.Microorganisms · 2024Article
- Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus.Scientific reports · 2024Article
- Advances in multi-omics integrated analysis methods based on the gut microbiome and their applications.Frontiers in microbiology · 2024Review
- Review
- Bioarchaeological and paleogenomic profiling of the unusual Neolithic burial from Grotta di Pietra Sant'Angelo (Calabria, Italy).Scientific reports · 2023Article
- Ultra-high performance liquid chromatography high-resolution mass spectrometry for metabolomic analysis of dental calculus from Duke Alessandro Farnese and Maria D'Aviz.Scientific reports · 2023Article
- Permafrost preservation reveals proteomic evidence for yak milk consumption in the 13Communications biology · 2023Article
- Data-independent acquisition boosts quantitative metaproteomics for deep characterization of gut microbiota.NPJ biofilms and microbiomes · 2023Article
- Studying ancient human oral microbiomes could yield insights into the evolutionary history of noncommunicable diseases.F1000Research · 2023Review
- The Hidden Secrets of the Dental Calculus: Calibration of a Mass Spectrometry Protocol for Dental Calculus Protein Analysis.International journal of molecular sciences · 2022Article
- Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave.Communications biology · 2022Article
- Ancient dental calculus preserves signatures of biofilm succession and interindividual variation independent of dental pathology.PNAS nexus · 2022Article
- Paleoproteomics.Chemical reviews · 2022Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The composition of ancient oral microbiomes has recently become accessible owing to advanced biomolecular methods such as metagenomics and metaproteomics, but the utility of metaproteomics for such analyses is less explored. Here, we use quantitative metaproteomics to characterize the dental calculus associated with the remains of 21 humans retrieved during the archeological excavation of the medieval (ca. 1100-1450 CE) cemetery of Tjærby, Denmark. We identify 3671 protein groups, covering 220 bacterial species and 81 genera across all medieval samples. The metaproteome profiles of bacterial and human proteins suggest two distinct groups of archeological remains corresponding to health-predisposed and oral disease-susceptible individuals, which is supported by comparison to the calculus metaproteomes of healthy living individuals. Notably, the groupings identified by metaproteomics are not apparent from the bioarchaeological analysis, illustrating that quantitative metaproteomics has the potential to provide additional levels of molecular information about the oral health status of individuals from archeological contexts.
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