Evidence map›Paper›PMID 30459225›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp.

Malgorzata A Mis, Yang Yang, Brian S Tanaka, Carolina Gomis-Perez, Shujun Liu, Fadia Dib-Hajj, Talia Adi, Rolando Garcia-Milian, Betsy R Schulman, Sulayman D Dib-Hajj and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 96 citations in OpenAlex.

  1. Article
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  6. Review
  7. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  8. NaBrain communications · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Decoding Pain: Next-Generation In Vitro Systems for Mechanistic Insights and Drug Discovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Directions for analgesic development.Journal of anesthesia and translational medicine · 2024
    Review
  18. Article
  19. Article
  20. The pain target NaPflugers Archiv : European journal of physiology · 2024
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Malgorzata A MisDepartment of Neurology, Yale University, New Haven, Connecticut 06510.ORCID 0000-0001-9476-5466
Yang YangDepartment of Neurology, Yale University, New Haven, Connecticut 06510.ORCID 0000-0001-6417-3654
Brian S TanakaDepartment of Neurology, Yale University, New Haven, Connecticut 06510.ORCID 0000-0002-6678-6478
Carolina Gomis-PerezDepartment of Neurology, Yale University, New Haven, Connecticut 06510.ORCID 0000-0002-6818-4403
Shujun LiuDepartment of Neurology, Yale University, New Haven, Connecticut 06510.
Fadia Dib-HajjDepartment of Neurology, Yale University, New Haven, Connecticut 06510.ORCID 0000-0002-5026-1351
Talia AdiDepartment of Neurology, Yale University, New Haven, Connecticut 06510.ORCID 0000-0002-3423-3318
Rolando Garcia-MilianBioinformatics Support Program, Cushing/Whitney Medical Library, Yale University, New Haven, Connecticut 06510.ORCID 0000-0003-1557-566X
Betsy R SchulmanDepartment of Neurology, Yale University, New Haven, Connecticut 06510.ORCID 0000-0002-9368-9091
Sulayman D Dib-HajjDepartment of Neurology, Yale University, New Haven, Connecticut 06510.ORCID 0000-0002-4137-1655
Stephen G WaxmanDepartment of Neurology, Yale University, New Haven, Connecticut 06510, stephen.waxman@yale.edu.ORCID 0000-0001-5718-7177
Yale University · USWhitney Museum of American Art · US

Funding

High Performance Computing Instrumentation for the Yale Center for Genome AnalysiS10OD018521 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2015 to 2015
$890k
NIH HHS S10 OD018521
6 · The paper itself

Abstract

Pain is a complex process that involves both detection in the peripheral nervous system and perception in the CNS. Individual-to-individual differences in pain are well documented, but not well understood. Here we capitalized on inherited erythromelalgia (IEM), a well characterized human genetic model of chronic pain, and studied a unique family containing related IEM subjects with the same disease-causing Na

Indexed as

Induced Pluripotent Stem CellsResilience, PsychologicalAdultChildChronic PainErythromelalgiaExcitatory Postsynaptic PotentialsExomeFemaleGanglia, SpinalHumansImmunohistochemistryIndividualityKCNQ Potassium ChannelsMaleMembrane PotentialsKCNQ Potassium ChannelsNAV1.7 Voltage-Gated Sodium ChannelSCN9A protein, humandynamic clampinduced pluripotent stem cellspainpotassium channelvoltage-gated sodium channelwhole exome sequencing

Identifiers

PMID30459225
PMCPMC6335750
OpenAlexW2901895724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.