Evidence map›Paper›PMID 30459196›Full record

ArticlemBio2018

Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis.

Rajendra Upadhya, Lorina G Baker, Woei C Lam, Charles A Specht, Maureen J Donlin, Jennifer K Lodge

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 90 citations in OpenAlex.

  1. Review
  2. Acetylation and accessibility ofCell surface (Amsterdam, Netherlands) · 2026
    Article
  3. Molecular Architecture ofbioRxiv : the preprint server for biology · 2026
    Article
  4. A review of the current anti-New microbes and new infections · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Evolutionary uniqueeLife · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Measuring Stress Phenotypes in Cryptococcus neoformans.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  18. Article
  19. Antifungal Effect of Vitamin DJournal of fungi (Basel, Switzerland) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rajendra UpadhyaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Lorina G BakerDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Woei C LamDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Charles A SpechtDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Maureen J DonlinEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Jennifer K LodgeDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Washington University in St. Louis · USSaint Louis University · USUniversity of Massachusetts Chan Medical School · US

Funding

Preclinical studies of a Cryptococcus vaccine for AIDS patientsR01AI125045 · NIAID · WASHINGTON UNIVERSITY · PI LEVITZ, STUART MICHAEL, LODGE, JENNIFER K. · 2016 to 2025
$7.1M
ROLE OF MACROPHAGES IN CRYPTOCOCCAL INFECTIONSR01AI025780 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 1987 to 2019
$7.1M
Chitosan in CryptococcusR01AI072195 · NIAID · WASHINGTON UNIVERSITY · PI LODGE, JENNIFER K. · 2008 to 2018
$3.5M
NIAID NIH HHS R01 AI025780NIAID NIH HHS R01 AI072195NIAID NIH HHS R01 AI125045
6 · The paper itself

Abstract

Chitin is an essential component of the cell wall of

Indexed as

AmidohydrolasesAnimalsChitinCryptococcosisCryptococcus neoformansFemaleFungal ProteinsGene Expression Regulation, FungalMiceMice, Inbred CBAPoint MutationVirulenceVirulence FactorsAmidohydrolasesChitinchitin deacetylaseFungal ProteinsVirulence Factorscatalytic sitecell wall localizationchitin deacetylasechitosanfungal virulencemetal binding site

Identifiers

PMID30459196
PMCPMC6247093
OpenAlexW2901914345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.