ArticleJournal of the International Neuropsychological Society : JINS2019
Cognitive Indicators of Preclinical Behavioral Variant Frontotemporal Dementia in MAPT Carriers.
Article in Journal of the International Neuropsychological Society : JINS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review.Aging and disease · 2024Pooled it
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Language impairments in behavioural variant frontotemporal dementia: a comparative study with semantic dementia.Journal of neurology · 2026Article
- Executive Function Deficits in Genetic Frontotemporal Dementia: Results From the GENFI Study.Neurology. Genetics · 2025Article
- Speech and language markers of neurodegeneration: a call for global equity.Brain : a journal of neurology · 2023Review
- Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.Annals of neurology · 2023Article
- Language impairment in the genetic forms of behavioural variant frontotemporal dementia.Journal of neurology · 2023Article
- The New Zealand Genetic Frontotemporal Dementia Study (FTDGeNZ): a longitudinal study of pre-symptomatic biomarkers.Journal of the Royal Society of New Zealand · 2023Article
- Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations.Journal of neurology · 2022Article
- Proposed research criteria for prodromal behavioural variant frontotemporal dementia.Brain : a journal of neurology · 2022Article
- Cognitive composites for genetic frontotemporal dementia: GENFI-Cog.Alzheimer's research & therapy · 2022Article
- Recognition memory and divergent cognitive profiles in prodromal genetic frontotemporal dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Language in Behavioral Variant Frontotemporal Dementia: Another Stone to Be Turned in Latin America.Frontiers in neurology · 2021Review
- Emotion recognition of morphed facial expressions in presymptomatic and symptomatic frontotemporal dementia, and Alzheimer's dementia.Journal of neurology · 2021Article
- Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Bipolar Disorder Among Patients Diagnosed With Frontotemporal Dementia.The Journal of neuropsychiatry and clinical neurosciences · 2020Review
- An update on genetic frontotemporal dementia.Journal of neurology · 2019Review
- Psychological and Cognitive Markers of Behavioral Variant Frontotemporal Dementia-A Clinical Neuropsychologist's View on Diagnostic Criteria and Beyond.Frontiers in neurology · 2019Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesThe cognitive indicators of preclinical behavioral variant Frontotemporal Dementia (bvFTD) have not been identified. To investigate these indicators, we compared cross-sectional performance on a range of cognitive measures in 12 carriers of pathogenic MAPT mutations not meeting diagnostic criteria for bvFTD (i.e., preclinical) versus 32 demographically-matched familial non-carriers (n = 44). Studying preclinical carriers offers a rare glimpse into emergent disease, environmentally and genetically contextualized through comparison to familial controls.
methodsEvaluating personnel blinded to carrier status administered a standardized neuropsychological battery assessing attention, speed, executive function, language, memory, spatial ability, and social cognition. Results from mixed effect modeling were corrected for multiplicity of comparison by the false discovery rate method, and results were considered significant at p < .05. To control for potential interfamilial variation arising from enrollment of six families, family was treated as a random effect, while carrier status, age, gender, and education were treated as fixed effects.
resultsGroup differences were detected in 17 of 31 cognitive scores and spanned all domains except spatial ability. As hypothesized, carriers performed worse on specific measures of executive function, and social cognition, but also on measures of attention, speed, semantic processing, and memory storage and retrieval.
conclusionsMost notably, group differences arose on measures of memory storage, challenging long-standing ideas about the absence of amnestic features on neuropsychological testing in early bvFTD. Current findings provide important and clinically relevant information about specific measures that may be sensitive to early bvFTD, and advance understanding of neurocognitive changes that occur early in the disease. (JINS, 2019, 25, 184-194).
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