Trial reportCritical care (London, England)2018
Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial.
Trial report in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protocolized Care for Early Septic Shock
Dexmedetomidine Improve Microcirculatory Alterations in Initial Resuscitated Septic Shock Patients
The Prognostic Value of Simultaneous Assessment of Microcirculation Alteration With Sublingual Microcirculation and Near-infrared Spectroscopy on the Acute Respiratory Distress Syndrome of Various Phenotypes
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- A Barrier to Defend - Models of Pulmonary Barrier to Study Acute Inflammatory Diseases.Frontiers in immunology · 2022Pooled it
- Microcirculatory perfusion disturbances following cardiopulmonary bypass: a systematic review.Critical care (London, England) · 2020Pooled it
- Sublingual microcirculatory assessment on admission independently predicts the outcome of old intensive care patients suffering from shock.Scientific reports · 2024Trial
- Direct assessment of microcirculation in shock: a randomized-controlled multicenter study.Intensive care medicine · 2023Trial
- Early warning scores and peripheral perfusion index: A Comparative assessment for 30-day mortality in critical patients in emergency departments.Irish journal of medical science · 2026Article
- The OxyCam: A novel hand-held vital microscope for quantitative measurement of microcirculatory perfusion and oxygenation.Journal of intensive medicine · 2026Article
- Current and future strategies aiming at reducing catecholamine exposure in septic shock.Critical care (London, England) · 2026Review
- The effects of lipopolysaccharide-induced endotoxic shock on the intestinal microcirculatory perfusion: an experimental study in pigs.Intensive care medicine experimental · 2026Article
- Physiological determinants and the red blood cells transfusion decision-making process in non-bleeding critically ill patients: a comprehensive narrative review.Intensive care medicine · 2026Review
- Electroacupuncture-inspired neuroimmune modulation in sepsis: evidence appraisal and ICU trial-design priorities.Frontiers in medicine · 2026Review
- Endothelial glycocalyx thickness in cats with naturally occurring trauma or non-traumatic illness: an exploratory study.Frontiers in veterinary science · 2026Article
- Effects of fluids on sublingual microcirculation: a point of view review.Annals of intensive care · 2025Review
- Beyond Standard Parameters: Precision Hemodynamic Monitoring in Patients on Veno-Arterial ECMO.Journal of personalized medicine · 2025Review
- ECMO in Refractory Septic Shock: Patient Selection, Timing and Hemodynamic Targets.Journal of clinical medicine · 2025Review
- Biomarkers of Microcirculatory Dysfunction in Sepsis: A Pilot Prospective Observational Study.Critical care explorations · 2025Observational
- Minimally-Invasive Imaging of Sublingual Vessels-A New Method to Study Microvascular Changes in Mice.Life (Basel, Switzerland) · 2025Article
- Effects of Endotoxemia and Blood Pressure on Microcirculation and Noradrenaline Needs With or Without Dexmedetomidine in Beagle Dogs-A Blinded Cross-Over Study.Animals : an open access journal from MDPI · 2025Article
- Development of an Extended Cardiovascular SOFA Score Component Reflecting Cardiac Dysfunction with Improved Survival Prediction in Sepsis: An Exploratory Analysis in the Sepsis and Elevated Troponin (SET) Study.Journal of intensive care medicine · 2025Article
- Monitoring of perioperative tissue perfusion and impact on patient outcomes.Journal of cardiothoracic surgery · 2025Review
- Systemic and Cardiac Microvascular Dysfunction in Hypertension.International journal of molecular sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundWe sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis.
methodsThis was a prospective, formally designed substudy of participants in the Protocolized Care in Early Septic Shock (ProCESS) trial. We recruited from six sites with the equipment and training to perform these study procedures. All subjects were adults with septic shock, and each was assigned to alternative resuscitation strategies. The two main analyses assessed (1) the impact of resuscitation strategies on microcirculatory perfusion parameters and (2) the association of microcirculatory perfusion with 60-day in-hospital mortality. We measured sublingual microcirculatory perfusion using sidestream dark field in vivo video microscopy at the completion of the 6-h ProCESS resuscitation protocol and then again at 24 and 72 h.
resultsWe enrolled 207 subjects (demographics were similar to the overall ProCESS cohort) and observed 40 (19.3%) deaths. There were no differences in average perfusion characteristics between treatment arms. Analyzing the relationship between microcirculatory perfusion and mortality, we found an association between vascular density parameters and mortality. Total vascular density (beta = 0.006, p < 0.003), perfused vascular density (beta = 0.005, p < 0.04), and De Backer score (beta = 0.009, p < 0.01) were higher overall in survivors in a generalized estimating equation model, and this association was significant at the 72-h time point (p < 0.05 for each parameter).
conclusionsMicrocirculatory perfusion did not differ between three early septic shock treatment arms. We found an association between microcirculatory perfusion parameters of vascular density at 72 h and mortality.
trial registrationClinicalTrials.gov, NCT00510835 . Registered on August 2, 2007.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.