ArticleJournal of neuroengineering and rehabilitation2018
Regenerative peripheral nerve interfaces for real-time, proportional control of a Neuroprosthetic hand.
Article in Journal of neuroengineering and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05008185 (Regenerative Peripheral Nerve Interfaces to Treat Painful Digit and Hand Neuromas After Amputation), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regenerative Peripheral Nerve Interfaces to Treat Painful Digit and Hand Neuromas After Amputation: A Prospective Observational Trial"
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Regenerative Peripheral Nerve Interfaces (RPNIs) in Animal Models and Their Applications: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Experimental Testing of Bionic Peripheral Nerve and Muscle Interfaces: Animal Model Considerations.Frontiers in neuroscience · 2019Pooled it
- Use of regenerative peripheral nerve interfaces and intramuscular electrodes to improve prosthetic grasp selection: a case study.Journal of neural engineering · 2022Trial
- Ultrasound-activated piezoelectric muscle constructs for tissue-engineered regenerative peripheral nerve interfaces.Bioactive materials · 2027Article
- Effective Interventions in Restoring Mobility and Relieving Pain After Lower Limb Amputation.Journal of orthopaedics and sports medicine · 2026Article
- Regenerative Peripheral Nerve Interface (RPNI) and vascularized Denervated Muscle Targets (VDMT): a preclinical rabbit model as a translational feasibility and methodological platform.Journal of translational medicine · 2026Article
- Improving nerve and muscle function: an exploration of targeted nerve function replacement following differential delay periods in a rat model.Journal of neuroengineering and rehabilitation · 2025Article
- A Robust Neuromuscular Interface to Restore Lost Function in People with Amputations.Research square · 2025Article
- Targeted Muscle Reinnervation-an Up-to-Date Review: Evidence, Indications, and Technique.Archives of plastic surgery · 2025Article
- Investigating the Feasibility and Safety of Osseointegration With Neural Interfaces for Advanced Prosthetic Control.Cureus · 2025Review
- Beyond Amputation: Functional Restoration after Upper-Extremity Limb Loss.Journal of hand surgery global online · 2025Article
- The Latest Research Progress on Bionic Artificial Hands: A Systematic Review.Micromachines · 2024Review
- Merging Humans and Neuroprosthetics through Regenerative Peripheral Nerve Interfaces.Seminars in plastic surgery · 2024Review
- Regenerative Peripheral Nerve Interface Surgery: Anatomic and Technical Guide.Plastic and reconstructive surgery. Global open · 2023Article
- Long-term upper-extremity prosthetic control using regenerative peripheral nerve interfaces and implanted EMG electrodes.Journal of neural engineering · 2023Article
- Regenerative peripheral nerve interface prevents neuroma formation after peripheral nerve transection.Neural regeneration research · 2023Article
- Toward higher-performance bionic limbs for wider clinical use.Nature biomedical engineering · 2023Review
- Use of Vascularized, Denervated Muscle Targets for Prevention and Treatment of Upper-Extremity Neuromas.Journal of hand surgery global online · 2023Article
- Effects of regenerative peripheral nerve interface on dorsal root ganglia neurons following peripheral axotomy.Frontiers in neuroscience · 2022Article
- Comparison of Myoelectric Control Schemes for Simultaneous Hand and Wrist Movement using Chronically Implanted Electromyography: A Case SeriesAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
introductionRegenerative peripheral nerve interfaces (RPNIs) are biological constructs which amplify neural signals and have shown long-term stability in rat models. Real-time control of a neuroprosthesis in rat models has not yet been demonstrated. The purpose of this study was to: a) design and validate a system for translating electromyography (EMG) signals from an RPNI in a rat model into real-time control of a neuroprosthetic hand, and; b) use the system to demonstrate RPNI proportional neuroprosthesis control.
methodsAnimals were randomly assigned to three experimental groups: (1) Control; (2) Denervated, and; (3) RPNI. In the RPNI group, the extensor digitorum longus (EDL) muscle was dissected free, denervated, transferred to the lateral thigh and neurotized with the residual end of the transected common peroneal nerve. Rats received tactile stimuli to the hind-limb via monofilaments, and electrodes were used to record EMG. Signals were filtered, rectified and integrated using a moving sample window. Processed EMG signals (iEMG) from RPNIs were validated against Control and Denervated group outputs.
resultsVoluntary reflexive rat movements produced signaling that activated the prosthesis in both the Control and RPNI groups, but produced no activation in the Denervated group. Signal-to-Noise ratio between hind-limb movement and resting iEMG was 3.55 for Controls and 3.81 for RPNIs. Both Control and RPNI groups exhibited a logarithmic iEMG increase with increased monofilament pressure, allowing graded prosthetic hand speed control (R
conclusionEMG signals were successfully acquired from RPNIs and translated into real-time neuroprosthetic control. Signal contamination from muscles adjacent to the RPNI was minimal. RPNI constructs provided reliable proportional prosthetic hand control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.