Evidence map›Paper›PMID 30458815›Full record

ArticleBMC surgery2018

Adrenal cavernous hemangioma: a case report.

Carlo V Feo, Alessandro De Troia, Massimo Pedriali, Simone Sala, Maria Chiara Zatelli, Paolo Carcoforo, Claudio F Feo

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Retroperitoneal ovarian venous hemangioma: A case report.Experimental and therapeutic medicine · 2026
    Article
  4. Article
  5. Article
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  8. Article
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  10. Article
  11. [Adrenal cavernous hemangioma: A case report and literature review].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021
    Review
  12. Article
  13. Article
  14. Adrenal hemangioma: A rare presentation of bleeding incidentaloma: Case report.International journal of surgery case reports · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carlo V FeoDepartment of Surgery, Unit of General Surgery, Azienda USL di Ferrara, and University of Ferrara, Ferrara, Italy. cvfeo@unife.it.ORCID http://orcid.org/0000-0003-0699-5689
Alessandro De TroiaDepartment of Surgery, Unit of Surgery 2, S. Anna University Hospital of Ferrara, and University of Ferrara, Ferrara, Italy.
Massimo PedrialiDepartment of Diagnostic Imaging and Laboratory Medicine, Unit of Anatomic Pathology, S. Anna University Hospital of Ferrara, and University of Ferrara, Ferrara, Italy.
Simone SalaDepartment of Diagnostic Imaging and Laboratory Medicine, Unit of Radiology, S. Anna University Hospital of Ferrara, Ferrara, Italy.
Maria Chiara ZatelliDepartment of Medical Sciences, Section of Endocrinology and Internal Medicine, S. Anna University Hospital of Ferrara, and University of Ferrara, Ferrara, Italy.
Paolo CarcoforoDepartment of Surgery, Unit of Surgery 2, S. Anna University Hospital of Ferrara, and University of Ferrara, Ferrara, Italy.
Claudio F FeoDepartment of Clinical and Experimental Medicine, Unit of General Surgery 2, University of Sassari, Sassari, Italy.
University of Ferrara · ITUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdrenal cavernous hemangiomas are very rare benign tumors that usually present as incidental findings on abdominal imaging. Preoperative differential diagnosis from other benign or malignant adrenal neoplasms may be challenging. CASE PRESENTATION: A 70-year old man was referred for an 8-cm abdominal mass incidentally discovered on a contrast-enhanced computed tomography (CT) performed to investigate a pulmonary nodule. Biochemical tests ruled out any endocrine dysfunction and iodine 123 metaiodobenzylguanidine whole body scintiscan single-photon emission CT excluded a pheocromocitoma. Findings on magnetic resonance imaging were non-specific and the patient was elected for a left adrenalectomy. Histopathological diagnosis revealed a cavernous hemangioma. A portion of the resected tissue was tested for drug sensitivity to mitotane, doxorubicin, and sunitinib.

conclusionsAdrenal hemangioma is a rare disease but should be included in the differential diagnosis of adrenal tumors. The surgical resection is generally required to exclude malignant disease, resolve pressure-related symptoms, and prevent retroperitoneal hemorrhage. Although specific features in diagnostic imaging are often lacking, if the diagnosis is established preoperatively a laparoscopic adrenalectomy can be performed due to the benign nature of the lesion. Doxorubicin and sunitinib were both capable of reducing primary culture cell viability, this suggest that similar drugs may be useful in the medical treatment of adrenal hemangiomas.

Indexed as

AdrenalectomyAdrenal Gland NeoplasmsAgedDiagnosis, DifferentialHemangioma, CavernousHumansIncidental FindingsLung NeoplasmsMagnetic Resonance ImagingMaleRare DiseasesTomography, X-Ray ComputedAdrenalectomyAdrenal glandAdrenal tumorCavernous hemangiomaIncidentaloma

Identifiers

PMID30458815
PMCPMC6247755
OpenAlexW2900619224

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.