Evidence map›Paper›PMID 30458752›Full record

ArticleBMC pregnancy and childbirth2018

First trimester medication use in pregnancy in Cameroon: a multi-hospital survey.

Aminkeng Zawuo Leke, Helen Dolk, Maria Loane, Karen Casson, Nkwati Michel Maboh, Susan Etta Maeya, Lerry Dibo Ndumbe, Pauline Bessem Nyenti, Obale Armstrong, Derick Etiendem

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in BMC pregnancy and childbirth, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Aminkeng Zawuo LekeDepartment of Nursing, School of Health Sciences, Biaka University Institute of Buea-Cameroon, PO BOX 77, Buea, Cameroon. zawuol@gmail.com.ORCID http://orcid.org/0000-0001-7268-6820
Helen DolkCentre for Maternal, Fetal and Infant Research, Institute for Nursing and Health Research, Ulster University, Shore Rd Newtownabbey, BT370QB, Ulster, Ireland.
Maria LoaneCentre for Maternal, Fetal and Infant Research, Institute for Nursing and Health Research, Ulster University, Shore Rd Newtownabbey, BT370QB, Ulster, Ireland.
Karen CassonCentre for Maternal, Fetal and Infant Research, Institute for Nursing and Health Research, Ulster University, Shore Rd Newtownabbey, BT370QB, Ulster, Ireland.
Nkwati Michel MabohDepartment of Nursing, School of Health Sciences, Biaka University Institute of Buea-Cameroon, PO BOX 77, Buea, Cameroon.
Susan Etta MaeyaDepartment of Nursing, School of Health Sciences, Biaka University Institute of Buea-Cameroon, PO BOX 77, Buea, Cameroon.
Lerry Dibo NdumbeDepartment of Nursing, School of Health Sciences, Biaka University Institute of Buea-Cameroon, PO BOX 77, Buea, Cameroon.
Pauline Bessem NyentiDepartment of Nursing, School of Health Sciences, Biaka University Institute of Buea-Cameroon, PO BOX 77, Buea, Cameroon.
Obale ArmstrongDepartment of Nursing, School of Health Sciences, Biaka University Institute of Buea-Cameroon, PO BOX 77, Buea, Cameroon.
Derick EtiendemDepartment of Nursing, School of Health Sciences, Biaka University Institute of Buea-Cameroon, PO BOX 77, Buea, Cameroon.
University of Buea · CMUniversity of Ulster · GB

Funding

Ulster University Vice Chancellor Research Award
6 · The paper itself

Abstract

backgroundThere is a paucity of epidemiological data on medication use in pregnancy in Cameroon.

methodsBetween March and August 2015, 795 pregnant women attending 8 urban and 12 rural hospitals in Cameroon for antenatal (ANC) or other care were interviewed on first trimester medication use using structured questionnaires. Multivariate logistic regression was used to analyse the association of 18 sociodemographic factors with medication use.

resultsA total of 582 (73.2%) women took at least one orthodox (Western) medication during the first trimester, 543 (68.3%) women a non-pregnancy related orthodox medication, and 336 (42.3%)women a pregnancy related orthodox medication. 44% of the women took anti-infectives including antimalarials (33.6%) and antibiotics (20.8%).The other most common medications were analgesics (48.8%) and antianaemias (38.6%). Sulfadoxine/pyrimethamine, contraindicated in the first trimester of pregnancy, was the most commonly used antimalarial(13% of women).0.2% of women reported antiretroviral use. Almost 80% of all orthodox medications consumed by women were purchased from the hospital. 12.8% of the women self-prescribed. Health unit and early gestational age at ANC booking were consistent determinants of prescribing of non-pregnancy related, pregnancy related and anti-infective medications. Illness and opinion on the safety of orthodox medications were determinants of the use of non-pregnancy related medications and anti-infectives. Age and parity were associated only with non-pregnancy related medications.

conclusionThis study has confirmed the observations of studies across Africa indicating the increasing use of medications during pregnancy. This is an indication that access to medicine is improving and more emphasis now must be placed on medication safety systems targeting pregnant women, especially during the first trimester when the risk of teratogenicity is highest.

Indexed as

Pregnancy Trimester, FirstAdultAnalgesicsAnti-Bacterial AgentsAntimalarialsCameroonDrug CombinationsDrug PrescriptionsFemaleHumansLogistic ModelsMultivariate AnalysisPregnancyPregnancy ComplicationsPrenatal CarePyrimethamineAnalgesicsAnti-Bacterial AgentsAntimalarialsDrug Combinationsfanasil, pyrimethamine drug combinationPyrimethamineSulfadoxineCameroondeterminantsdrug safetydrug useMedicationpharmacoepidemiologypharmacovigilancepregnancy

Identifiers

PMID30458752
PMCPMC6245902
OpenAlexW2900757533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.