Evidence map›Paper›PMID 30458744›Full record

ArticleBMC urology2018

Bilateral Xp11.2 translocation renal cell carcinoma: a case report.

Takashi Karashima, Takahira Kuno, Naoto Kuroda, Hirofumi Satake, Satoshi Fukata, Masakazu Chikazawa, Chiaki Kawada, Ichiro Yamasaki, Taro Shuin, Makoto Hiroi and 1 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Takashi KarashimaDepartment of Urology, Kochi University, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, 783-8505, Japan. karasima@kochi-u.ac.jp.
Takahira KunoDepartment of Urology, Kochi University, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, 783-8505, Japan.
Naoto KurodaDepartment of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi-Shi, Kochi, 780-0062, Japan.
Hirofumi SatakeDepartment of Urology, Kochi University, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, 783-8505, Japan.
Satoshi FukataDepartment of Urology, Kochi University, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, 783-8505, Japan.
Masakazu ChikazawaDepartment of Urology, Izumino Hospital, Kochi-Shi, Kochi, 781-0011, Japan.
Chiaki KawadaDepartment of Urology, Kochi University, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, 783-8505, Japan.
Ichiro YamasakiDepartment of Urology, Kochi University, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, 783-8505, Japan.
Taro ShuinDepartment of Urology, Kochi University, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, 783-8505, Japan.
Makoto HiroiLaboratory of Diagnostic Pathology, Kochi Medical School Hospital, Kohasu, Oko, Nankoku, Kochi, 783-8505, Japan.
Keiji InoueDepartment of Urology, Kochi University, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, 783-8505, Japan.
Kōchi University · JPJapanese Red Cross Kochi Hospital · JPKochi Medical School Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundXp11.2 translocation renal cell carcinoma (RCC) is a rare variety of a kidney neoplasm. We report a case of bilateral Xp11.2 translocation RCC occurring metachronously and discuss this very rare entity with reference to the literature. CASE PRESENTATION: The patient was a 56-year-old woman who presented with a right renal tumor. The patient had undergone left radical nephrectomy 7 years previously, which resulted in a histopathological diagnosis of clear cell RCC. Open right partial nephrectomy was performed under the presumptive diagnosis of recurrence of clear cell RCC. The present right renal tumor was pathologically diagnosed Xp11.2 translocation RCC. More than 70% of the tumor cells in the present right tumor were strongly positive for transcription factor E3 (TFE3) expression by immunohistochemical analysis with an anti-TFE3 antibody. A break-apart of the TFE3 genes in the bilateral tumors was identified by fluorescence in situ hybridization analysis. Real time-polymerase chain reaction analysis for the alveolar soft part sarcoma locus-TFE3 fusion gene was performed, which gave a positive result in the bilateral tumors. Pathological comparison of each of the tumors might lead to a final diagnosis of Xp11.2 translocation RCC occurring metachronously.

conclusionsWe present the bilateral Xp11.2 translocation RCC. A combination of immunohistochemical, cytogenetic and molecular biological approaches allowed the final diagnosis of such a rare RCC.

Indexed as

Carcinoma, Renal CellChromosomes, Human, XFemaleGenetic Diseases, X-LinkedHumansKidney NeoplasmsMiddle AgedTranslocation, GeneticASPL-TFE3BilateralRenal cell carcinomaXp11.2 translocation

Identifiers

PMID30458744
PMCPMC6245707
OpenAlexW2900494022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.