ArticleBMC plant biology2018
Disruption of ureide degradation affects plant growth and development during and after transition from vegetative to reproductive stages.
Article in BMC plant biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Loss ofPlants (Basel, Switzerland) · 2026Article
- Coral-Associated Bacteria Provide Alternative Nitrogen Source for Symbiodiniaceae Growth in Oligotrophic Environment.Microorganisms · 2025Article
- Article
- Allantoate Amidohydrolase OsAAH is Essential for Preharvest Sprouting Resistance in Rice.Rice (New York, N.Y.) · 2024Article
- Stomatal properties of Arabidopsis cauline and rice flag leaves and their contributions to seed production and grain yield.Journal of experimental botany · 2023Article
- Combined Metabolomic and Transcriptomic Analysis Reveals Allantoin Enhances Drought Tolerance in Rice.International journal of molecular sciences · 2022Article
- A New Perspective on the Role of Glutamine Synthetase in Nitrogen Remobilization in Wheat (International journal of molecular sciences · 2021Article
- Xanthine-derived metabolites enhance chlorophyll degradation in cotyledons and seedling growth during nitrogen deficient condition inPlant signaling & behavior · 2021Article
- Nucleoside Metabolism Is Induced in Common Bean During Early Seedling Development.Frontiers in plant science · 2021Article
- Mechanistic Insight of Allantoin in Protecting Tomato Plants Against Ultraviolet C Stress.Plants (Basel, Switzerland) · 2020Article
- Ureide metabolism in Arabidopsis thaliana is modulated by C:N balance.Journal of plant research · 2020Article
- Role of ureides in source-to-sink transport of photoassimilates in non-fixing soybean.Journal of experimental botany · 2020Article
- Interactive effects of polyamines and arbuscular mycorrhiza in modulating plant biomass, NEnvironmental science and pollution research international · 2020Article
- Discovery of an ultraspecific triuret hydrolase (TrtA) establishes the triuret biodegradation pathway.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe ureides allantoin and allantoate are major metabolic intermediates of purine catabolism with high nitrogen-to-carbon ratios. Ureides play a key role in nitrogen utilization in ureide-type legumes, but their effects on growth and development in non-legume plants are poorly understood. Here, we examined the effects of knocking out genes encoding ureide-degrading enzymes, allantoinase (ALN) and allantoate amidohydrolase (AAH), on the vegetative-to-reproductive transition and subsequent growth of Arabidopsis plants.
resultsThe ureide-degradation mutants (aln and aah) showed symptoms similar to those of nitrogen deficiency: early flowering, reduced size at maturity, and decreased fertility. Consistent with these phenotypes, carbon-to-nitrogen ratios and nitrogen-use efficiencies were significantly decreased in ureide-degradation mutants; however, adding nitrogen to irrigation water did not alleviate the reduced growth of these mutants. In addition to nitrogen status, levels of indole-3-acetic acid and gibberellin in five-week-old plants were also affected by the aln mutations. To test the possibility that ureides are remobilized from source to sink organs, we measured ureide levels in various organs. In wild-type plants, allantoate accumulated predominantly in inflorescence stems and siliques; this accumulation was augmented by disruption of its catabolism. Mutants lacking ureide transporters, ureide permeases 1 and 2 (UPS1 and UPS2), exhibited phenotypes similar to those of the ureide-degradation mutants, but had decreased allantoate levels in the reproductive organs. Transcript analysis in wild-type plants suggested that genes involved in allantoate synthesis and ureide transport were coordinately upregulated in senescing leaves.
conclusionsThis study demonstrates that ureide degradation plays an important role in supporting healthy growth and development in non-legume Arabidopsis during and after transition from vegetative to reproductive stages.
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