ArticleThe Journal of neuropsychiatry and clinical neurosciences2019
Brain Volumetric Correlates of Right Unilateral Versus Bitemporal Electroconvulsive Therapy for Treatment-Resistant Depression.
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in The Journal of neuropsychiatry and clinical neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Ultrabrief pulse electroconvulsive therapy for depression: a systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Meta-analytic Evidence for Volume Increases in the Medial Temporal Lobe After Electroconvulsive Therapy.Biological psychiatry · 2021Pooled it
- Electroconvulsive Therapy (ECT) and Repetitive Transcranial Magnetic Stimulation (rTMS), Benefits and Adverse Effects in Patients with Depression: A Scoping Review.Journal of clinical medicine · 2026Review
- Relationship between hippocampal volume and treatment response before and after escitalopram administration in patients with depression.Translational psychiatry · 2025Article
- Computational Models of High-Definition Electroconvulsive Therapy for Focal or Multitargeting Treatment.The journal of ECT · 2025Article
- Comparison of High-Charge Protocol vs. Dose Titration Protocol in Bilateral ECT: Evaluation of Antidepressant Effectiveness and EEG Parameters.Journal of clinical medicine · 2025Article
- Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.Nature communications · 2025Article
- Article
- Brain volumetric correlates of electroconvulsive therapy versus transcranial magnetic stimulation for treatment-resistant depression.Journal of affective disorders · 2023Article
- Cerebro-cerebellar functional neuroplasticity mediates the effect of electric field on electroconvulsive therapy outcomes.Translational psychiatry · 2023Article
- The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go?Biological psychiatry · 2022Review
- Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy.Journal of psychiatry & neuroscience : JPN · 2021Article
- Article
- Biophysical mechanisms of electroconvulsive therapy-induced volume expansion in the medial temporal lobe: A longitudinal in vivo human imaging study.Brain stimulationArticle
- Electroconvulsive Therapy: Mechanisms of Action, Clinical Considerations, and Future Directions.Harvard review of psychiatryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Marta CanoFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Erik LeeFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Narcís CardonerFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Ignacio Martínez-ZalacaínFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Jesús PujolFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Nikos MakrisFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Michael HenryFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Esther ViaFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Rosa Hernández-RibasFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Oren Contreras-RodríguezFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
José M MenchónFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Mikel UrretavizcayaFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Carles Soriano-MasFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Joan A CamprodonFrom the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona (MC, IM-Z, RH-R, OC-R, JMM, MU, CS-M); the Department of Clinical Sciences, School of Medicine, University of Barcelona (MC, IM-Z, RH-R, JMM, MU); CIBERSAM, Carlos III Health Institute, Madrid (MC, NC, JP, EV, RH-R, OC-R, JMM, MU, CS-M); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MC, EL, NM, MH, JAC); the Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona (NC); the Radiology Department, MRI Research Unit, Hospital del Mar, Barcelona (JP); Sant Joan de Déu Barcelona-Children's Hospital, Barcelona (EV); and the Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (CS-M).
Bellvitge University Hospital · ES
Funding
A Transdiagnostic Assessment of Electroconvulsive Therapy Modulation of Anhedonia and Reward circuitry: Targets, Biomarkers and Predictors of ResponseR01MH112737 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A · 2017 to 2021
$3.8MNIMH NIH HHS R01 MH112737
Abstract
objectiveThe selection of a bitemporal (BT) or right unilateral (RUL) electrode placement affects the efficacy and side effects of ECT. Previous studies have not entirely described the neurobiological underpinnings of such differential effects. Recent neuroimaging research on gray matter volumes is contributing to our understanding of the mechanism of action of ECT and could clarify the differential mechanisms of BT and RUL ECT.
methodsTo assess the whole-brain gray matter volumetric changes observed after treating patients with treatment-resistant depression with BT or RUL ECT, the authors used MRI to assess 24 study subjects with treatment-resistant depression (bifrontotemporal ECT, N=12; RUL ECT, N=12) at two time points (before the first ECT session and after ECT completion).
resultsStudy subjects receiving BT ECT showed gray matter volume increases in the bilateral limbic system, but subjects treated with RUL ECT showed gray matter volume increases limited to the right hemisphere. The authors observed significant differences between the two groups in midtemporal and subcortical limbic structures in the left hemisphere.
conclusionsThese findings highlight that ECT-induced gray matter volume increases may be specifically observed in the stimulated hemispheres. The authors suggest that electrode placement may relevantly contribute to the development of personalized ECT protocols.
Indexed as
AdultCerebral CortexDepressive Disorder, Treatment-ResistantElectroconvulsive TherapyFemaleHumansLimbic SystemMagnetic Resonance ImagingMaleMiddle AgedTreatment OutcomeBitemporal Electroconvulsive TherapyBrain MorphometryRight Unilateral Electroconvulsive TherapyTreatment-Resistant Depression
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.