ArticleBiomaterials2019
Active wrinkles to drive self-cleaning: A strategy for anti-thrombotic surfaces for vascular grafts.
Article in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Nature-inspired biomaterial innovations to counter medical device-associated infections.Biomaterials science · 2026Review
- Nanostructured Hydrogels: A Method to Prevent Biofilms on Implantable Medical Devices.Gels (Basel, Switzerland) · 2026Review
- Ascorbate elastomer-coated ePTFE grafts inhibit neointimal hyperplasia and enhance vascular healing.Bioactive materials · 2026Article
- Interventional Management of Renal Cell Carcinoma with Inferior Vena Cava Tumor Thrombus and Secondary Deep Venous Thrombosis: A Case Report.Cancer management and research · 2026Article
- A bio-inspired screwed small-diameter vascular graft for endotheliazation and arterial regeneration.Bioactive materials · 2025Article
- A soft robotic total artificial hybrid heart.Nature communications · 2025Article
- Improving the hemocompatibility of a porohyperelastic layered vascular graft using luminal reversal microflows.Journal of the mechanical behavior of biomedical materials · 2024Article
- Optimizing the Porohyperelastic Response of a Layered Compliance Matched Vascular Graft to Promote Luminal Self-Cleaning.Journal of biomechanical engineering · 2023Article
- Topographic de-adhesion in the viscoelastic limit.Journal of the Royal Society, Interface · 2023Article
- Hemocompatibility of micropatterned biomaterial surfaces is dependent on topographical feature size.Frontiers in physiology · 2022Article
- Parametric excitation of wrinkles in elastic sheets on elastic and viscoelastic substrates.The European physical journal. E, Soft matter · 2021Article
- Noninvasive thrombectomy of graft by nano-magnetic ablating particles.Scientific reports · 2021Article
- Wrinkling instabilities for biologically relevant fiber-reinforced composite materials with a case study of Neo-Hookean/Ogden-Gasser-Holzapfel bilayer.Biomechanics and modeling in mechanobiology · 2020Article
- Bioinspired Multiscale Wrinkling Patterns on Curved Substrates: An Overview.Nano-micro letters · 2020Review
- Dynamic Luminal Topography: A Potential Strategy to Prevent Vascular Graft Thrombosis.Frontiers in bioengineering and biotechnology · 2020Article
- Undulatory topographical waves for flow-induced foulant sweeping.Science advances · 2019Article
- Micro- and Nanotopography Sensitive Bacterial Attachment Mechanisms: A Review.Frontiers in microbiology · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The inner surfaces of arteries and veins are naturally anti-thrombogenic, whereas synthetic materials placed in blood contact commonly experience thrombotic deposition that can lead to device failure or clinical complications. Presented here is a bioinspired strategy for self-cleaning anti-thrombotic surfaces using actuating surface topography. As a first test, wrinkled polydimethylsiloxane planar surfaces are constructed that can repeatedly transition between smooth and wrinkled states. When placed in contact with blood, these surfaces display markedly less platelet deposition than control samples. Second, for the specific application of prosthetic vascular grafts, the potential of using pulse pressure, i.e. the continual variation of blood pressure between systole and diastole, to drive topographic actuation was investigated. Soft cylindrical tubes with a luminal surface that transitioned between smooth and wrinkled states were constructed. Upon exposure to blood under continual pressure pulsation, these cylindrical tubes also showed reduced platelet deposition versus control samples under the same fluctuating pressure conditions. In both planar and cylindrical cases, significant reductions in thrombotic deposition were observed, even when the wrinkles had wavelengths of several tens of μm, far larger than individual platelets. We speculate that the observed thrombo-resistance behavior is attributable to a biofilm delamination process in which the bending energy within the biofilm overcomes interfacial adhesion. This novel strategy to reduce thrombotic deposition may be applicable to several types of medical devices placed into the circulatory system, particularly vascular grafts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.