Evidence map›Paper›PMID 30458306›Full record

Trial reportNeuroImage2019

Pharmacological stress impairs working memory performance and attenuates dorsolateral prefrontal cortex glutamate modulation.

Eric A Woodcock, Mark K Greenwald, Dalal Khatib, Vaibhav A Diwadkar, Jeffrey A Stanley

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
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  6. Article
  7. Cue-induced Magnetic Resonance Spectroscopy of Glutamate in Addiction Research: Current Evidence, Pros, and Cons.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Review
  8. Article
  9. Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric A WoodcockBrain Imaging Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA; Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: eric.woodcock@yale.edu.
Mark K GreenwaldSubstance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Dalal KhatibBrain Imaging Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Vaibhav A DiwadkarBrain Imaging Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Jeffrey A StanleyBrain Imaging Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.

Funding

Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
Biobehavioral Studies of Opioid Seeking: Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid AbstinenceR01DA015462 · NIDA · WAYNE STATE UNIVERSITY · PI GREENWALD, MARK K · 2003 to 2019
$5.5M
Neuropharmacological investigation of frontostriatal network function and nicotine seeking behavior in current smokersF31DA040369 · NIDA · WAYNE STATE UNIVERSITY · PI WOODCOCK, ERIC ANDREW · 2016 to 2017
$61k
NIDA NIH HHS F31 DA040369NIDA NIH HHS R01 DA015462NIDA NIH HHS T32 DA022975
6 · The paper itself

Abstract

Working memory processes are associated with the dorsolateral prefrontal cortex (dlPFC). Prior research using proton functional magnetic resonance spectroscopy (

Indexed as

Adrenergic alpha-2 Receptor AntagonistsAdultBrain MappingDouble-Blind MethodFemaleGlutamic AcidHumansHydrocortisoneMagnetic Resonance ImagingMaleMemory, Short-TermPrefrontal CortexStress, PsychologicalYohimbineYoung AdultAdrenergic alpha-2 Receptor AntagonistsGlutamic AcidHydrocortisoneYohimbine(1)H fMRSDorsolateral prefrontal cortexGlutamateNoradrenalineStressWorking memory

Identifiers

PMID30458306
PMCPMC6491044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.