Evidence map›Paper›PMID 30458277›Full record

ArticleFree radical biology & medicine2019

Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism.

Lei Liu, Mary K Vollmer, Abdullah S Ahmad, Victoria M Fernandez, Hocheol Kim, Sylvain Doré

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  18. The Nrf2 Pathway in Ischemic Stroke: A Review.Molecules (Basel, Switzerland) · 2021
    Review
  19. Neuroprotective and Anti-Inflammatory Effects ofMolecules (Basel, Switzerland) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lei LiuDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Mary K VollmerDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Abdullah S AhmadDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Victoria M FernandezDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Hocheol KimDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Sylvain DoréDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Departments of Neurology, Psychiatry, Pharmaceutics, Psychology, and Neuroscience, University of Florida, Gainesville, FL, USA. Electronic address: sdore@ufl.edu.
University of Florida · USKyung Hee University · KR

Funding

Role of Prostaglandin Receptors in StrokeR01NS046400 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2003 to 2014
$3.0M
Better Understanding of the Neuroprotective Mechanisms of Korean Ginseng in StrokR01AT007429 · NCCIH · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2012 to 2016
$2.2M
NCCIH NIH HHS R01 AT007429NINDS NIH HHS R01 NS046400
6 · The paper itself

Abstract

The transcriptional factor Nrf2, a master regulator of oxidative stress and inflammation that are tightly linked to the development and progression of cerebral ischemia pathology, plays a vital role in inducing the endogenous neuroprotective process. Here, hypoxic-ischemia (HI) was performed in adult Nrf2 knockout and wildtype mice that were orally pretreated either with standardized Korean red ginseng extract (Ginseng) or dimethyl fumarate (DMF), two candidate Nrf2 inducers, to determine whether the putative protection was through an Nrf2-dependent mechanism involving the attenuation of reactive gliosis. Results show that Nrf2 target cytoprotective genes were distinctly elevated following HI. Pretreatment with Ginseng or DMF elicited robust neuroprotection against the deterioration of acute cerebral ischemia damage in an Nrf2-dependent manner as revealed by the reductions of neurological deficits score, infarct volume and brain edema, as well as enhanced expression levels of Nrf2 target antioxidant proteins and anti-inflammation mediators. In both ischemic striatum and cortex, the dynamic pattern of attenuated reactive gliosis in astrocytes and microglia, including affected astrocytic dysfunction in glutamate metabolism and water homeostasis, correlated well with the Nrf2-dependent neuroprotection by Ginseng or DMF. Furthermore, such neuroprotective benefits extended to the late phase of ischemic brain damage after HI, as evidenced by improvements in neurobehavioral outcomes, infarct volume and brain edema. Overall, pretreatment with Ginseng or DMF identically attenuates reactive gliosis and confers long-lasting neuroprotective efficacy against ischemic brain damage through an Nrf2-dependent mechanism. This study also provides new insight into the profitable contribution of reactive gliosis in the Nrf2-dependent neuroprotection in acute brain injury.

Indexed as

AnimalsAquaporin 4AstrocytesCalcium-Binding ProteinsCarotid ArteriesCerebral CortexCerebrovascular DisordersCorpus StriatumDimethyl FumarateDisease Models, AnimalGene Expression RegulationGlial Fibrillary Acidic ProteinGliosisHumansHypoxia-Ischemia, BrainMaleAif1 protein, mouseAqp4 protein, mouseAquaporin 4Calcium-Binding ProteinsDimethyl FumarateGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseMicrofilament ProteinsNAD(P)H Dehydrogenase (Quinone)Neuroprotective AgentsNfe2l2 protein, mouseNF-E2-Related Factor 2Nqo1 protein, mousePlant ExtractsAquaporin 4AstrocyteGlutamine synthetaseIschemiaMicrogliaStroke

Identifiers

PMID30458277
PMCPMC6362849
OpenAlexW2900846894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.