ArticlePloS one2018
Relapse to smoking and health-related quality of life: Secondary analysis of data from a study of smoking relapse prevention.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relapse prevention interventions for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- The impact of smoking on lung cancer patients.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- The short-term impact ofProceedings. Biological sciences · 2024Article
- Dietary supplementation with a wild green oat extract (Frontiers in nutrition · 2024Article
- Do post-quitting experiences predict smoking relapse among former smokers in Australia and the United Kingdom? Findings from the International Tobacco Control Surveys.Drug and alcohol review · 2022Article
- Identification of smoking cessation phenotypes as a basis for individualized counseling: An explorative real-world cohort study.Tobacco induced diseases · 2022Article
- Estimation of Lifetime QALYs Based on Lifestyle Behaviors.International journal of environmental research and public health · 2021Article
- Association of Health-Related Quality of Life with Atherosclerotic Cardiovascular Disease: Lifetime Risk Pooling Project.American journal of preventive cardiology · 2021Article
- Smoking cessation and related factors in middle-aged and older Chinese adults: Evidence from a longitudinal study.PloS one · 2020Article
- Circumstances Around Cigarette Use after Enforced Abstinence From Smoking in an American Prison.Journal of addiction medicineArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundPrevious studies have shown that smoking and smoking cessation may be associated with health-related quality of life (HRQoL). In this study, we compared changes in HRQoL in people who maintained abstinence with people who had relapsed to smoking.
methodsThis was a secondary analysis of data from a trial of a relapse prevention intervention in 1,407 short-term quitters. The European Quality of Life -5 Dimensions (EQ-5D) measured HRQoL at baseline, 3 and 12 months. Smoking outcome was continuous abstinence from 2 to 12 months, and 7-day smoking at 3 and 12 months. We used nonparametric test for differences in EQ-5D utility scores, and chi-square test for dichotomised response to each of the five EQ-5D dimensions. Multivariable regression analyses were conducted to evaluate associations between smoking relapse and HRQoL or anxiety/depression problems.
resultsThe mean EQ-5D tariff score was 0.8252 at baseline. People who maintained abstinence experienced a statistically non-significant increase in the EQ-5D score (mean change 0.0015, P = 0.88), while returning to smoking was associated with a statistically significant decrease in the EQ-5D score (mean change -0.0270, P = 0.004). After adjusting for multiple baseline characteristics, the utility change during baseline and 12 months was statistically significantly associated with continuous abstinence, with a difference of 0.0288 (95% CI: 0.0006 to 0.0571, P = 0.045) between relapsers and continuous quitters. The only difference in quality of life dimensions between those who relapsed and those who maintained abstinence was in the proportion of participants with anxiety/depression problems at 12 months (30% vs. 22%, P = 0.001). Smoking relapse was associated with a simultaneous increase in anxiety/depression problems.
conclusionsPeople who achieve short-term smoking abstinence but subsequently relapse to smoking have a reduced quality of life, which appears mostly due to worsening of symptoms of anxiety and depression. Further research is required to more fully understand the relationship between smoking and health-related quality of life, and to develop cessation interventions by taking into account the impact of anxiety or depression on smoking.
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