Evidence map›Paper›PMID 30457843›Full record

ReviewBiochemistry2019

Understanding and Engineering Distributed Biochemical Pathways in Microbial Communities.

Xinyun Cao, Joshua J Hamilton, Ophelia S Venturelli

Abstract readReview
In one paragraph

Review in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Why cellular computations challenge our design principles.Seminars in cell & developmental biology · 2025
    Review
  2. The cultivation ofFrontiers in microbiology · 2025
    Article
  3. Deciphering and designing microbial communities by genome-scale metabolic modelling.Computational and structural biotechnology journal · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xinyun CaoDepartment of Biochemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Joshua J HamiltonDepartment of Biochemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Ophelia S VenturelliDepartment of Biochemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.ORCID 0000-0003-2200-1963

Funding

Elucidating the molecular and ecological design principles of stability and assembly of the human gut microbiotaR35GM124774 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Ophelia Venturelli · 2017 to 2026
$2.9M
NIGMS NIH HHS R35 GM124774
6 · The paper itself

Abstract

Microbiomes impact nearly every environment on Earth by modulating the molecular composition of the environment. Temporally changing environmental stimuli and spatial organization are major variables shaping the structure and function of microbiomes. The web of interactions among members of these communities and between the organisms and the environment dictates microbiome functions. Microbial interactions are major drivers of microbiomes and are modulated by spatiotemporal parameters. A mechanistic and quantitative understanding of ecological, molecular, and environmental forces shaping microbiomes could inform strategies to control microbiome dynamics and functions. Major challenges for harnessing the potential of microbiomes for diverse applications include the development of predictive modeling frameworks and tools for precise manipulation of microbiome behaviors.

Indexed as

Models, BiologicalBiological EvolutionComputational BiologyGame TheoryGenome, MicrobialMicrobiotaSpatio-Temporal AnalysisSynthetic Biology

Identifiers

PMID30457843
PMCPMC6733022

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.