ArticleEmerging infectious diseases2018
Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant.
Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
145 citing papers in PubMed, 4 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Pooled it
- A systematic review of the epidemiology of Hepatitis E virus infection in South - Eastern Asia.Virulence · 2021Pooled it
- Treatment for chronic hepatitis E virus infection: A systematic review and meta-analysis.Journal of viral hepatitis · 2021Pooled it
- Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis.BMC veterinary research · 2021Pooled it
- Viral entry defines the hepatitis E virus species barrier in murine hepatocytes.Emerging microbes & infections · 2026Article
- Viral pathogens in urban rats: A one health systematic review of global surveillance evidence.One health (Amsterdam, Netherlands) · 2026Review
- The evolution of in vitro culture systems for the study of hepatitis E virus infection.Virology · 2026Review
- Rodent-borne pathogens as economic and zoonotic health threat to livestock farming: a review.One health (Amsterdam, Netherlands) · 2026Review
- Multi-Organ RNA Virome Profiling of Edible Rodents Reveals Potential Zoonotic Viral Exposure at the Wildlife-Livestock-Human Interface in Southwest China.Pathogens (Basel, Switzerland) · 2026Article
- Molnupiravir is effective against hepatitis E virus infection in an animal model.Hepatology communications · 2026Article
- Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact.Nature communications · 2026Review
- Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt.Science advances · 2026Article
- Article
- Development of a Fully Automated, High-Throughput Molecular Assay for Detection of Rat Hepatitis E Virus in Routine Diagnostics.Journal of medical virology · 2026Article
- Metatranscriptomics profiling reveals rodent- and shrew-borne viral diversity and evolutionary relationships in Guangzhou, China.Virologica Sinica · 2026Article
- The silent spread of Hepatitis E in India - from epidemiological insight to public health action: a comprehensive review.Infection · 2026Review
- Highly divergent virome in wild rodents of Xinjiang, China: Implications for rodent origin of porcine reproductive and respiratory syndrome virus 1.Zoological research · 2026Article
- Burden of rodent-borne viruses in rodents and zoonotic risk in humans in Cambodia.Microbiology spectrum · 2026Article
- Evidence of Rat Hepatitis E Virus Circulation through Wastewater Surveillance, Central Argentina.Emerging infectious diseases · 2026Article
- Performance of Elecsys Anti-HEV IgG and IgM Assays for the Detection of Acute, Recent or Past Hepatitis E Virus Infection.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species Orthohepevirus C (HEV-C), which circulates in rats and is highly divergent from HEV-A, is unknown. We report a liver transplant recipient with hepatitis caused by HEV-C infection. We detected HEV-C RNA in multiple clinical samples and HEV-C antigen in the liver. The complete genome of the HEV-C isolate had 93.7% nt similarity to an HEV-C strain from Vietnam. The patient had preexisting HEV antibodies, which were not protective against HEV-C infection. Ribavirin was an effective treatment, resulting in resolution of hepatitis and clearance of HEV-C viremia. Testing for this zoonotic virus should be performed for immunocompromised and immunocompetent patients with unexplained hepatitis because routine hepatitis E diagnostic tests may miss HEV-C infection. HEV-C is also a potential threat to the blood product supply.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.