Evidence map›Paper›PMID 30457357›Full record

ArticleJournal of drug targeting

Transport and delivery of interferon-α through epithelial tight junctions via pH-responsive poly(methacrylic acid-grafted-ethylene glycol) nanoparticles.

Mary Caldorera-Moore, Julia E Vela Ramirez, Nicholas A Peppas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of drug targeting. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Nanoparticles Bounded to Interfering RNAs as a Therapy for Pancreatic Cancer: A Systematic Review.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Engineered biomimetic micro/nano-materials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2023
    Review
  7. Review
  8. Review
  9. Review
  10. A Review of Nanotechnology for Treating Dysfunctional Placenta.Frontiers in bioengineering and biotechnology · 2022
    Review
  11. Review
  12. Engineering precision nanoparticles for drug delivery.Nature reviews. Drug discovery · 2021
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mary Caldorera-Moorea Department of Biomedical Engineering , Louisiana Tech University , Ruston , LA , USA.
Julia E Vela Ramirezb McKetta Department of Chemical Engineering , The University of Texas at Austin , Austin , TX , USA.
Nicholas A Peppasb McKetta Department of Chemical Engineering , The University of Texas at Austin , Austin , TX , USA.
The University of Texas at Austin · USLouisiana Tech University · US

Funding

TRANS-NETWORK PROJECTSU54CA143837 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FERRARI, MAURO · 2009 to 2014
$10.8M
NCI NIH HHS U54 CA143837
6 · The paper itself

Abstract

Whereas significant advancements have been made in our fundamental understanding of cancer, they have not yet translated into effective clinical cancer treatments. One of the areas that has the potential to improve the efficacy of cancer therapies is the development of novel drug delivery technologies. In particular, the design of pH-sensitive polymeric complexation hydrogels may allow for targeted oral delivery of a wide variety of chemotherapeutic drugs and proteins. In this work, poly(methacrylic acid-grafted-ethylene glycol) hydrogel nanoparticles were synthesised, characterised, and studied as matrix-type, diffusion-controlled, pH-responsive carriers to enable the oral delivery of the chemotherapeutic agent interferon alpha (IFN-α). The biophysical mechanisms controlling the transport of IFN-α were investigated using a Caco-2/HT29-MTX co-culture as a gastrointestinal (GI) tract model. The synthesised nanoparticles exhibited pH-responsive swelling behaviour and allowed the permeation of IFN-α through the tight junctions of the developed cellular GI epithelium model. These studies demonstrate the capabilities of these particles to contribute to the improved oral delivery of protein chemotherapeutics.

Indexed as

Caco-2 CellsCell Line, TumorDrug CarriersDrug Delivery SystemsEthylene GlycolHT29 CellsHumansHydrogelsHydrogen-Ion ConcentrationInterferon-alphaIntestinal MucosaMethacrylatesNanoparticlesPolyethylene GlycolsTight JunctionsDrug CarriersEthylene GlycolHydrogelsInterferon-alphaMethacrylatesmethacrylic acidPolyethylene GlycolsCaco-2 cell linesGI tract delivery systemsinterferon alpha (IFN-α)pH-sensitive hydrogel nanoparticlesResponsive hydrogels

Identifiers

PMID30457357
PMCPMC6522304
OpenAlexW2900494925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.