Evidence map›Paper›PMID 30457247›Full record

ArticleActa clinica Croatica2018

Cost-Benefit Analysis of the Introduction of Mp-Mri Guided Biopsies in Croatia.

Ivan Pezelj, Igor Tomašković, Karolina Bolanča Čulo, Luka Novosel, Miroslav Tomić, Ante Reljić, Josip Katušić, Matej Knežević, Sven Nikles, Matea Pirša and 3 more

Open access · greenAbstract read
In one paragraph

Article in Acta clinica Croatica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ivan PezeljDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
Igor TomaškovićDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
Karolina Bolanča ČuloDepartment of Radiology, Sestre milosrdnice University Hospital Center.
Luka NovoselDepartment of Radiology, Sestre milosrdnice University Hospital Center.
Miroslav TomićDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
Ante ReljićDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
Josip KatušićDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
Matej KneževićDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
Sven NiklesDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
Matea PiršaDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
Danijel JustinicDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
Diana ZadravecDepartment of Radiology, Sestre milosrdnice University Hospital Center.
Boris RužićDepartment of Urology, Sestre milosrdnice University Hospital Center, Zagreb.
University of Osijek · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to determine differential expression of TFF1, TFF2 and TFF3 genes and proteins in breast tumor subtypes. In addition, we investigated the correlation between TFF genes within tumor subgroups, and TFF genes with clinical and pathologic characteristics of the tumor. Study group included 122 patients with surgically removed breast tumors. Samples were investigated using qRT-PCR and immunohistochemistry. TFF1 and TFF3 genes and proteins were expressed in breast tumors, while the levels of TFF2 gene and protein expression were very low or undetectable. TFF1 was significantly more expressed in benign tumors, while TFF3 was more expressed in malignant tumors. Gene and protein expression of both TFF1 and TFF3 was greater in lymph node-negative tumors, hormone positive tumors, tumors with moderate levels of Ki67 expression, and in grade II tumors. A strong positive correlation was found between TFF1 and TFF3 genes, and the expression of both negatively correlated with Ki67 and the level of tumor histologic differentiation. Our results suggest that TFF1 and TFF3, but not TFF2, may have a role in breast tumor pathogenesis and could be used in the assessment of tumor differentiation and malignancy.

Indexed as

Breast NeoplasmsTrefoil Factor-1Trefoil Factor-2Trefoil Factor-3BiopsyFemaleHumansMuscle ProteinsPeptidesMuscle ProteinsPeptidesTFF1 protein, humanTFF2 protein, humanTFF3 protein, humanTrefoil Factor-1Trefoil Factor-2Trefoil Factor-3Prostate cancer, cost benefitProstate mp-MRI

Identifiers

PMID30457247
PMCPMC12231100
OpenAlexW3024905190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.