SynthesisEpigenomics2018
Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.
Synthesis in Epigenomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts.Genome medicine · 2024Pooled it
- Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress.Molecular psychiatry · 2022Pooled it
- DNA Methylation as a Mediator of Cardiovascular Disease Risk in Relation to PTSD Severity: Identification of Potential Epigenetic Biomarkers.medRxiv : the preprint server for health sciences · 2026Article
- Examining the timing of trauma, PTSD onset, and DNA methylation: A multicohort investigation of candidate CpG sites.Journal of psychiatric research · 2025Article
- Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD.Brain, behavior, and immunity · 2025Article
- Post-traumatic stress disorder: evolving conceptualization and evidence, and future research directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Mapping the epigenomic landscape of post-traumatic stress disorder in human cortical neurons.medRxiv : the preprint server for health sciences · 2024Article
- Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts.medRxiv : the preprint server for health sciences · 2024Article
- Epigenome-Wide Changes in the Cell Layers of the Vein Wall When Exposing the Venous Endothelium to Oscillatory Shear Stress.Epigenomes · 2023Article
- How can childhood maltreatment affect post-traumatic stress disorder in adult: Results from a composite null hypothesis perspective of mediation analysis.Frontiers in psychiatry · 2023Article
- Article
- Epigenetic citizenship and political claims-making: the ethics of molecularizing structural racism.BioSocieties · 2022Article
- An investigation into DNA methylation patterns associated with risk preference in older individuals.Epigenetics · 2022Article
- Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence.Biomedicines · 2022Review
- DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder.Psychiatry research · 2022Article
- Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans.Translational psychiatry · 2022Article
- Heterogeneous Mediation Analysis on Epigenomic PTSD and Traumatic Stress in a Predominantly African American Cohort.Journal of the American Statistical Association · 2022Article
- A narrative review of the epigenetics of post-traumatic stress disorder and post-traumatic stress disorder treatment.Frontiers in psychiatry · 2022Review
- Genome-wide differentially methylated genes associated with posttraumatic stress disorder and longitudinal change in methylation in rape survivors.Translational psychiatry · 2021Article
- Posttraumatic stress disorder: from gene discovery to disease biology.Psychological medicine · 2021Review
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 1 country.
Funding
Abstract
aimTrauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD. MATERIALS &
methodsWe conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium.
resultsTwo CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098).
conclusionPTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.