Evidence map›Paper›PMID 30456934›Full record

ArticleJournal of biomedical optics2018

Recovery of layered tissue optical properties from spatial frequency-domain spectroscopy and a deterministic radiative transport solver.

Sean T Horan, Adam R Gardner, Rolf Saager, Anthony J Durkin, Vasan Venugopalan

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sean T HoranUniversity of California, Department of Mathematics, Irvine, California, United States.
Adam R GardnerUniversity of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, Cali, United States.
Rolf SaagerUniversity of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, Cali, United States.
Anthony J DurkinUniversity of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, Cali, United States.
Vasan VenugopalanUniversity of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, Cali, United States.
Irvine University · USLinköping University · SEUniversity of California, Irvine · US

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
Mathematical, Computational and Systems BiologyT32EB009418 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D, NIE, QING · 2009 to 2019
$2.4M
NIBIB NIH HHS P41 EB015890NIBIB NIH HHS T32 EB009418
6 · The paper itself

Abstract

We present a method to recover absorption and reduced scattering spectra for each layer of a two-layer turbid media from spatial frequency-domain spectroscopy data. We focus on systems in which the thickness of the top layer is less than the transport mean free path   (  0.1  -  0.8l  *    )  . We utilize an analytic forward solver, based upon the N'th-order spherical harmonic expansion with Fourier decomposition   (  SHEFN  )   method in conjunction with a multistage inverse solver. We test our method with data obtained using spatial frequency-domain spectroscopy with 32 evenly spaced wavelengths within λ  =  450 to 1000 nm on six-layered tissue phantoms with distinct optical properties. We demonstrate that this approach can recover absorption and reduced scattering coefficient spectra for both layers with accuracy comparable with current Monte Carlo methods but with lower computational cost and potential flexibility to easily handle variations in parameters such as the scattering phase function or material refractive index. To our knowledge, this approach utilizes the most accurate deterministic forward solver used in such problems and can successfully recover properties from a two-layer media with superficial layer thicknesses.

Indexed as

Signal Processing, Computer-AssistedEquipment DesignModels, BiologicalMonte Carlo MethodOptical ImagingPhantoms, ImagingRefractometrySpectrum Analysisanalytic solverinverse problemspatial frequency domainstaged inversion

Identifiers

PMID30456934
PMCPMC6995875
OpenAlexW2943028726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.