ArticleThe European journal of neuroscience2019
Interactions between monoamine oxidase A rs1137070 and smoking on brain structure and function in male smokers.
Article in The European journal of neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Analysis of motor units with high-density surface electromyography: methodological considerations and physiological significance.European journal of applied physiology · 2026Review
- Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence.Brain imaging and behavior · 2024Article
- A synonymous mutation of rs1137070 cause the miceFrontiers in molecular neuroscience · 2024Article
- Reciprocal modulation between cigarette smoking and internet gaming disorder on participation coefficient within functional brain networks.Brain imaging and behavior · 2022Article
- Brain Magnetic Resonance Imaging Features of Nicotine-Dependent Individuals and Its Correlation with Polymorphisms of Dopamine D Receptor Gene.Contrast media & molecular imaging · 2022Article
- Monoamine oxidase inhibition in cigarette smokers: From preclinical studies to tobacco product regulation.Frontiers in neuroscience · 2022Review
- Effect of alcohol, tobacco, and cannabis co-use on gray matter volume in heavy drinkers.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021Article
- Addiction in focus: molecular mechanisms, model systems, circuit maps, risk prediction and the quest for effective interventions.The European journal of neuroscience · 2019Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. However, the underlying neural mechanisms of the gene × environment interactions remain largely unknown. In this study, we aimed to explore the interactive effects of the rs1137070 and cigarette smoking on gray matter volume (GMV) and functional connectivity strength (FCS). A total of 81 smokers and 42 nonsmokers were enrolled in the present study. Voxel-based morphometry analysis showed a significant rs1137070 genotype × smoking effect on the GMV of the left orbitofrontal cortex (OFC), such that individuals with risk allele had greater GMV among nonsmokers but not smokers. Meanwhile, rs1137070 variant and nicotine dependence interactively altered the FCS of the right hippocampus, the left inferior parietal lobule (IPL), the left dorsolateral prefrontal cortex and bilateral OFC. In addition, the FCS in the left IPL was correlated with smoking initiation and smoking years in smokers with the risk allele. These findings suggest that MAOA rs1137070 contributes to the susceptibility to nicotine dependence through its influence on brain circuits involved in reward and attention, and interacts with smoking in the progression.
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Registered trials
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