ArticleAging cell2019
Reconciling nutritional geometry with classical dietary restriction: Effects of nutrient intake, not calories, on survival and reproduction.
Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Neither caloric nor protein restriction increases the male lifespan of outbred short-lived fish.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Macronutrient balance dictates lifespan and reproduction in a beetle, Tenebrio molitor.The Journal of experimental biology · 2025Article
- The Integrative Life History of Maternal Effects.Integrative and comparative biology · 2024Review
- Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake.GeroScience · 2024Article
- Dietary restriction and lifespan: adaptive reallocation or somatic sacrifice?The FEBS journal · 2023Article
- Diet Composition, Anthropometrics, and Mortality Risk.International journal of environmental research and public health · 2022Article
- Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?Biogerontology · 2022Article
- Oxidative Damage Is Influenced by Diet But Unaffected by Selection for Early Age of Oviposition in the Marula Fly,Frontiers in physiology · 2022Article
- Review
- Transgenerational fitness effects of lifespan extension by dietary restriction inProceedings. Biological sciences · 2021Article
- Testing evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies (Drosophila melanogaster).Evolution; international journal of organic evolution · 2021Article
- Obesity and Male Reproduction; Placing the Western Diet in Context.Frontiers in endocrinology · 2021Review
- Good performance of turquoise killifish (Nothobranchius furzeri) on pelleted diet as a step towards husbandry standardization.Scientific reports · 2020Article
- Article
- Dietary macronutrient content, age-specific mortality and lifespan.Proceedings. Biological sciences · 2019Article
- Reconciling nutritional geometry with classical dietary restriction: Effects of nutrient intake, not calories, on survival and reproduction.Aging cell · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Dietary restriction (DR) is one of the main experimental paradigms to investigate the mechanisms that determine lifespan and aging. Yet, the exact nutritional parameters responsible for DR remain unclear. Recently, the advent of the geometric framework of nutrition (GF) has refocussed interest from calories to dietary macronutrients. However, GF experiments focus on invertebrates, with the importance of macronutrients in vertebrates still widely debated. This has led to the suggestion of a fundamental difference in the mode of action of DR between vertebrates and invertebrates, questioning the suggestion of an evolutionarily conserved mechanism. The use of dietary dilution rather than restriction in GF studies makes comparison with traditional DR studies difficult. Here, using a novel nonmodel vertebrate system (the stickleback fish, Gasterosteus aculeatus), we test the effect of macronutrient versus calorie intake on key fitness-related traits, both using the GF and avoiding dietary dilution. We find that the intake of macronutrients rather than calories determines both mortality risk and reproduction. Male mortality risk was lowest on intermediate lipid intakes, and female risk was generally reduced by low protein intakes. The effect of macronutrient intake on reproduction was similar between the sexes, with high protein intakes maximizing reproduction. Our results provide, to our knowledge, the first evidence that macronutrient, not caloric, intake predicts changes in mortality and reproduction in the absence of dietary dilution. This supports the suggestion of evolutionary conservation in the effect of diet on lifespan, but via variation in macronutrient intake rather than calories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.