ArticleAmerican journal of hematology2019
Multidisciplinary care results in similar maternal and perinatal mortality rates for women with and without SCD in a low-resource setting.
Article in American journal of hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Acute pain episodes, acute chest syndrome, and pulmonary thromboembolism in pregnancy.Hematology. American Society of Hematology. Education Program · 2022Pooled it
- Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta-Analysis.Ethiopian journal of health sciences · 2022Pooled it
- Hydroxyurea for primary stroke prevention in children with sickle cell anaemia in Nigeria (SPRING): a double-blind, multicentre, randomised, phase 3 trial.The Lancet. Haematology · 2022Trial
- Gynecologic and Reproductive Health in Patients with Sickle Cell Disease: Underrecognized Challenges and Care Management Opportunities.Journal of clinical medicine · 2026Review
- Proactive management to improve outcomes of high-risk pregnancy in people with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2025Review
- Prospective cohort study of eDiary acute pain assessments in sickle cell disease during third trimester and postpartum.Blood advances · 2025Article
- Red Blood Cell Exchange Apheresis in the Management of Acute Chest Syndrome: Case Study at Greater Accra Regional Hospital (Ghana)- Bone Marrow Transplant Unit (BMT-Ghana).Clinical case reports · 2025Article
- Patient-reported pregnancy loss and maternal complications: Insights from the sickle cell disease implementation consortium.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- High-Risk Consult Multidisciplinary Team in a Tertiary Maternity Unit: Changing Prevalence of Cases.Journal of multidisciplinary healthcare · 2025Article
- Screening for pulmonary hypertension in pregnant women with sickle cell disease in sub-Saharan Africa.AJOG global reports · 2024Article
- Preterm management of sickle cell crisis in a twin pregnancy with suboptimal antenatal care in a primary healthcare facility: A case report from Cameroon and literature review.Clinical case reports · 2023Article
- Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission.The Lancet. Haematology · 2023Review
- Most adults with severe HbSC disease are not treated with hydroxyurea.Blood advances · 2023Article
- Pregnancy outcomes in women with sickle cell disease in California.American journal of hematology · 2023Article
- Severe Maternal Morbidity and Mortality in Sickle Cell Disease in the National Inpatient Sample, 2012-2018.JAMA network open · 2023Article
- Maternal mortality among women with sickle cell disease in Jamaica over two decades (1998-2017).EClinicalMedicine · 2022Article
- Knowledge gaps in reproductive and sexual health in girls and women with sickle cell disease.British journal of haematology · 2021Review
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
Abstract
In Africa, the maternal mortality rate in sickle cell disease (SCD) is ~10%. Our team previously demonstrated an 89% decrease in mortality rate in a before-and-after feasibility study among women with SCD living in low-resource setting in Ghana. In the same cohort including additional participants with and without SCD, we used a prospective cohort design to test the hypothesis that implementing a multidisciplinary care team for pregnant women with SCD in low-resource setting will result in similar maternal and perinatal mortality rates compared to women without SCD. We prospectively enrolled pregnant women with and without SCD or trait and followed them up for 6-week postpartum. We tested the newborns of mothers with SCD for SCD. We recruited age and parity matched pregnant women without SCD or trait as the comparison group. Maternal and perinatal mortality rates were the primary outcomes. A total of 149 pregnant women with SCD (HbSS, 54; HbSC, 95) and 117 pregnant women without SCD or trait were included in the analysis. Post-intervention, maternal mortality rates were 1.3% and 0.9% in women with and without SCD, respectively (P = 1.00); the perinatal mortality rates were 7.4% and 3.4% for women with and without SCD, respectively (P = 0.164). Among the mothers with SCD, ~15% of newborns had SCD. Multidisciplinary care of pregnant women with SCD may reduce maternal and perinatal mortality rates to similar levels in pregnant women without SCD in low-resource settings. Newborns of mothers with SCD have a high rate of SCD.
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