Evidence map›Paper›PMID 30456592›Full record

ReviewHeart failure reviews2019

Atrial fibrillation in hypertrophic cardiomyopathy: prevalence, clinical impact, and management.

Lohit Garg, Manasvi Gupta, Syed Rafay Ali Sabzwari, Sahil Agrawal, Manyoo Agarwal, Talha Nazir, Jeffrey Gordon, Babak Bozorgnia, Matthew W Martinez

Abstract readComparative StudyReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 4 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  5. Evidence for a role of adverse sarcomere signaling in atrial fibrillation induction.Journal of molecular and cellular cardiology plus · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Lohit GargDivision of Cardiology, Lehigh Valley Health Network, 1200 S. Cedar Crest Blvd, Allentown, PA, 18103, USA. garg.medicine@gmail.com.ORCID 0000-0002-9387-4369
Manasvi GuptaMaulana Azad Medical College, Delhi, 110092, India.
Syed Rafay Ali SabzwariDivision of Cardiology, Lehigh Valley Health Network, 1200 S. Cedar Crest Blvd, Allentown, PA, 18103, USA.
Sahil AgrawalDivision of Cardiology, Brown University, Providence, RI, 02903, USA.
Manyoo AgarwalDepartment of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Talha NazirDivision of Cardiology, Lehigh Valley Health Network, 1200 S. Cedar Crest Blvd, Allentown, PA, 18103, USA.
Jeffrey GordonDivision of Cardiology, Lehigh Valley Health Network, 1200 S. Cedar Crest Blvd, Allentown, PA, 18103, USA.
Babak BozorgniaDivision of Cardiology, Lehigh Valley Health Network, 1200 S. Cedar Crest Blvd, Allentown, PA, 18103, USA.
Matthew W MartinezDivision of Cardiology, Lehigh Valley Health Network, 1200 S. Cedar Crest Blvd, Allentown, PA, 18103, USA.
Lehigh Valley Health Network · USBrown University · USLehigh Valley Hospital-Pocono · USMaulana Azad Medical College · INUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy characterized by left ventricular hypertrophy and spectrum of clinical manifestation. Atrial fibrillation (AF) is a common sustained arrhythmia in HCM patients and is primarily related to left atrial dilatation and remodeling. There are several clinical, electrocardiographic (ECG), and echocardiographic (ECHO) features that have been associated with development of AF in HCM patients; strongest predictors are left atrial size, age, and heart failure class. AF can lead to progressive functional decline, worsening heart failure and increased risk for systemic thromboembolism. The management of AF in HCM patient focuses on symptom alleviation (managed with rate and/or rhythm control methods) and prevention of complications such as thromboembolism (prevented with anticoagulation). Finally, recent evidence suggests that early rhythm control strategy may result in more favorable short- and long-term outcomes.

Indexed as

AdultAgedAged, 80 and overAnti-Arrhythmia AgentsAnticoagulantsAtrial FibrillationAtrial RemodelingCardiomyopathy, HypertrophicEchocardiographyElectrocardiographyHeart AtriaHeart FailureHumansMiddle AgedPrevalenceRisk FactorsAnti-Arrhythmia AgentsAnticoagulantsAntiarrhythmic agentsAtrial fibrillationHypertrophic cardiomyopathyTreatment

Identifiers

PMID30456592
OpenAlexW2901564477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.