Evidence map›Paper›PMID 30456573›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2019

Association between malnutrition-inflammation score and risk of subsequent self-reported bone fractures in prevalent kidney transplant recipients.

A Gaipov, O Cseprekal, P K Potukuchi, K Kabulbayev, A Remport, Z Mathe, M Talwar, V Balaraman, T Fülöp, J D Eason and 3 more

Abstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

A GaipovDepartment of Medicine, Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA.
O CseprekalDepartment of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.
P K PotukuchiDepartment of Medicine, Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA.
K KabulbayevDepartment of Nephrology, Kazakh National Medical University, Almaty, Kazakhstan.
A RemportDepartment of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.
Z MatheDepartment of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.
M TalwarMethodist Transplant Epidemiology Research Group, Methodist University Hospital Transplant Institute, 1211 Union Ave., Memphis, TN, 38104, USA.
V BalaramanMethodist Transplant Epidemiology Research Group, Methodist University Hospital Transplant Institute, 1211 Union Ave., Memphis, TN, 38104, USA.
T FülöpMedical Services, Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
J D EasonMethodist Transplant Epidemiology Research Group, Methodist University Hospital Transplant Institute, 1211 Union Ave., Memphis, TN, 38104, USA.
I MucsiDepartment of Medicine, Division of Nephrology and Multiorgan Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
C P KovesdyDepartment of Medicine, Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA.
M Z MolnarDepartment of Medicine, Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA. mzmolnar@uthsc.edu.
University of Tennessee Health Science Center · USSemmelweis University · HUKazakh National Medical University · KZMedical University of South Carolina · USMethodist University Hospital · USNational Medical Holding · KZUniversity Health Network · CA

Funding

Egészségügyi Tudományos Tanács 206/09KTIA-OTKA-EU 7KP-HUMAN-MB08-A-81231
6 · The paper itself

Abstract

Chronic inflammation and protein energy wasting (PEW) syndrome are common in kidney transplant recipients (KTR). The presence of inflammation and PEW syndrome can directly affect bone resorption and bone formation, leading to bone loss and fractures. We showed PEW is independently associated with new clinically detected bone fractures in prevalent KTR.

introductionKidney transplant recipients (KTR) have a 4-fold higher risk of fracture compared to the general population. Chronic inflammation and PEW syndrome are common in KTR and are associated with poor outcomes. We hypothesized that the Malnutrition-Inflammation Score (MIS), a validated measure of PEW, is associated with higher risk of bone fractures in KTR.

methodsThis prospective cohort study included 839 prevalent KTR from a Central European academic center. MIS, a semiquantitative instrument of PEW, was calculated at the study entry. Self-reported history of fractures was recorded during the 2-year follow-up period. The association between MIS and bone fractures was examined in logistic regression analyses with adjustment for age, gender, eGFR, smoking habits, history of pre-transplant bone fractures, and acute rejection.

resultsMean age was 51 ± 13 years, and 56% of patients were males with median (interquartile range) transplant vintage 69 (38-112) months, estimated glomerular filtration rate 55 ± 21 ml/min/1.73 m

conclusionThe MIS is independently associated with new clinically detected bone fractures in prevalent KTR.

Indexed as

AdultAgedFemaleHumansInflammationKidney TransplantationMaleMiddle AgedOsteoporotic FracturesPostoperative ComplicationsProspective StudiesProtein-Energy MalnutritionRisk FactorsSelf ReportSeverity of Illness IndexBone fractureKidney transplantMalnutrition–inflammation scoreProtein energy wasting

Identifiers

PMID30456573
OpenAlexW2900471038

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.